AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay

Natsuko Izumi; Akio Yamashita; Akihiro Iwamatsu; Rie Kurata; Hiroki Nakamura; Bonnie Saari; Hisashi Hirano; Philip Anderson; Shigeo Ohno

doi:10.1126/scisignal.2000468

Research ArticleMOLECULAR BIOLOGY

AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay

Natsuko Izumi¹,
Akio Yamashita¹,²,⁶,*,
Akihiro Iwamatsu³,
Rie Kurata¹,
Hiroki Nakamura⁴,
Bonnie Saari⁵,
Hisashi Hirano⁴,
Philip Anderson⁵, and
Shigeo Ohno¹,⁶,*

¹Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.
²Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Kawaguchi 332-0012, Japan.
³Protein Research Network Co., Ltd., Yokohama 236-0004, Japan.
⁴International Graduate School of Arts and Sciences, Yokohama City University, Yokohama 230-0045, Japan.
⁵Department of Genetics, University of Wisconsin, Madison, WI 53706, USA.
⁶Advanced Medical Research Center, Yokohama City University, Yokohama 236-0004, Japan.

↵*To whom correspondence should be addressed. E-mail: ohnos{at}med.yokohama-cu.ac.jp (S.O.); yamasita{at}yokohama-cu.ac.jp (A.Y.)

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Science Signaling 06 Apr 2010:
Vol. 3, Issue 116, pp. ra27
DOI: 10.1126/scisignal.2000468

Natsuko Izumi

1Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.

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Akio Yamashita

1Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.

2Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Kawaguchi 332-0012, Japan.

6Advanced Medical Research Center, Yokohama City University, Yokohama 236-0004, Japan.

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For correspondence: ohnos@med.yokohama-cu.ac.jp yamasita@yokohama-cu.ac.jp

Akihiro Iwamatsu

3Protein Research Network Co., Ltd., Yokohama 236-0004, Japan.

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Rie Kurata

1Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.

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Hiroki Nakamura

4International Graduate School of Arts and Sciences, Yokohama City University, Yokohama 230-0045, Japan.

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Bonnie Saari

5Department of Genetics, University of Wisconsin, Madison, WI 53706, USA.

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Hisashi Hirano

4International Graduate School of Arts and Sciences, Yokohama City University, Yokohama 230-0045, Japan.

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Philip Anderson

5Department of Genetics, University of Wisconsin, Madison, WI 53706, USA.

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Shigeo Ohno

1Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.

6Advanced Medical Research Center, Yokohama City University, Yokohama 236-0004, Japan.

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For correspondence: ohnos@med.yokohama-cu.ac.jp yamasita@yokohama-cu.ac.jp

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AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay

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