Contents
Vol 3, Issue 117
Contents
Research Article
- Identification of the miR-106b~25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation
A microRNA network regulates the tumor suppressor PTEN in prostate cancer.
Perspective
- Not Lost in Space: Trafficking in the Hedgehog Signaling Pathway
Protein kinase A orchestrates Hedgehog signaling from the base of the primary cilium.
Editors' Choice
- Localizing Lipids
VEGF-B regulates endothelial fatty acid transport and thereby lipid disposition by stimulating the production of fatty acid transport proteins.
- Debugging Metabolic Disease
The innate immune system may promote metabolic health through effects on gut microbes.
- The Persistent Smell in the Nucleus
Nuclear translocation of the cGMP-activated kinase EGL-4 is required for long-term odor adaptation in Caenorhabditis elegans.
- Inflamed About Epilepsy
Activation of Toll-like receptor 4 by the chromatin-associated protein HMGB1 triggers epileptic seizures in mice.
- Ligand-Independent ER Activation
cAMP activation of estrogen receptor α requires PKA-mediated phosphorylation of the arginine methyltransferase CARM1.
- Arsenic on the Fingers
Arsenic, a drug used clinically for leukemia, binds directly to an oncogenic protein, thereby promoting its degradation.
