20 April 2010
Vol 3, Issue 118
  • Contents

    • Research Article

    • Journal Club

    • Podcast

    • Editors' Choice

      • Keeping It Local

        Degradation of a growth factor receptor in the distal axon prevents its retrograde delivery and function as a long-distance neurotrophic factor.

      • A Hot Channel

        Snakes sense infrared radiation through the temperature-dependent activation of the TRPA1 ion channel.

      • Translation Under Stress

        ER stress selectively induces mRNA translation of a p53 isoform.

      • Deadly Diced DNA

        An enzyme that chops up RNA can be switched to DNA fragmentation and can trigger programmed cell death in worms.

      • Orphan No More

        A signaling complex serves as a synapse organizer that acts bidirectionally on both pre- and postsynaptic components.

      • Notch Protects the Mitochondria

        The Notch intracellular domain appears to serve as a cell survival factor by preventing mitochondrial damage.

      • Domain Swaps to Phenotype Shifts

        Systematic swapping of modular protein domains verifies a mechanism for generation of phenotypic diversity in yeast.

      • Yin-Yang T Cell Signaling

        Suppressive T cells repurpose inflammatory signaling pathways to promote their suppressive functions.

      • Receptor and Channel Pair

        A wavy hair phenotype reveals channel-receptor crosstalk in the mouse.

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article describing an example of the effectiveness of systems pharmacology in linking drug targets and disease genes through protein interaction networks, which is a step toward personalized medicine and safer drug prescribing. By integrating protein interaction data with data about the genetics underlying the cardiac disease long QT syndrome (LQTS), Berger et al. identified a network associated with this potentially fatal cardiac disorder. By combining this LQTS network with data about adverse effects of drugs, they identified drugs that may induce LQTS. The image shows an electrocardiogram trace represented by alternating drugs and chromosomes. [Image: Seth I. Berger, Ravi Iyengar, Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, NY]