Contents
Vol 3, Issue 118
Contents
Research Article
- Systems Pharmacology of Arrhythmias
Integration of drug and protein interaction data with genetic data enables prediction of adverse drug effects.
Journal Club
- Competitive Outgrowth of Neural Processes Arising from Long-Distance cAMP Signaling
Differences in neurite cyclic nucleotide concentrations regulate their differential outgrowth.
- TRIM Proteins: Another Class of Viral Victims
Influenza A virus suppresses the host interferon response by interfering with the RIG-I and TRIM25 antiviral molecules.
- T Cells with Commitment Issues
Some subsets of differentiated T cells retain phenotypic plasticity.
Podcast
- Science Signaling Podcast: 20 April 2010
Integrating interactome and genetics data allows researchers to predict adverse drug effects.
Editors' Choice
- Keeping It Local
Degradation of a growth factor receptor in the distal axon prevents its retrograde delivery and function as a long-distance neurotrophic factor.
- A Hot Channel
Snakes sense infrared radiation through the temperature-dependent activation of the TRPA1 ion channel.
- Deadly Diced DNA
An enzyme that chops up RNA can be switched to DNA fragmentation and can trigger programmed cell death in worms.
- Orphan No More
A signaling complex serves as a synapse organizer that acts bidirectionally on both pre- and postsynaptic components.
- Notch Protects the Mitochondria
The Notch intracellular domain appears to serve as a cell survival factor by preventing mitochondrial damage.
- Domain Swaps to Phenotype Shifts
Systematic swapping of modular protein domains verifies a mechanism for generation of phenotypic diversity in yeast.
- Yin-Yang T Cell Signaling
Suppressive T cells repurpose inflammatory signaling pathways to promote their suppressive functions.
- Receptor and Channel Pair
A wavy hair phenotype reveals channel-receptor crosstalk in the mouse.
