Contents

Contents

• Editorial Guide

  • Focus Issue: Teaching Tools and Learning Opportunities

    By Nancy R. Gough

    Science Signaling27 Apr 2010 : eg3 Full AccessRestricted Access

    Science Signaling provides authoring experience for students and resources for educators.

    • Abstract
    • Full Text
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• Research Articles

  • Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy

    By Christina H. Eng, Ker Yu, Judy Lucas, Eileen White, Robert T. Abraham

    Science Signaling27 Apr 2010 : ra31 Full AccessRestricted Access

    A volatile metabolic by-product can promote cell survival through the induction of autophagy.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • SUMOylation of the Transcriptional Co-Repressor KAP1 Is Regulated by the Serine and Threonine Phosphatase PP1

    By Xu Li, H. Helen Lin, Hanqing Chen, Xingzhi Xu, Hsiu-Ming Shih, David K. Ann

    Science Signaling27 Apr 2010 : ra32 Full AccessRestricted Access

    Two isoforms of protein phosphatase 1 coordinate the recovery of cells from genotoxic stress.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Evolution of CASK into a Mg²⁺-Sensitive Kinase

    By Konark Mukherjee, Manu Sharma, Reinhard Jahn, Markus C. Wahl, Thomas C. Südhof

    Science Signaling27 Apr 2010 : ra33 Full AccessRestricted Access

    The atypical kinase CASK evolved from a conventional Mg²⁺-dependent kinase.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Journal Club

  • Costimulatory Role of CXCR4 with Pre-TCR and Its Crosstalk with PI3K in β-Selection of Thymocytes

    By J. Ashik Ahamed, Periasamy Madhivadhani

    Science Signaling27 Apr 2010 : jc4 Full AccessRestricted Access

    Chemokine and pre-TCR signaling cooperate in β-selection of thymocytes and promote their subsequent proliferation.

    • Abstract
    • Full Text
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  • New Regulator for Energy Signaling Pathway in Plants Highlights Conservation Among Species

    By Anne K. Meyer, C. Friedrich H. Longin, Christian Klose, Andreas Hermann

    Science Signaling27 Apr 2010 : jc5 Full AccessRestricted Access

    The kinase CIPK links plant pathways involved in oxygen-sensing and carbohydrate metabolism.

    • Abstract
    • Full Text
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• Teaching Resources

  • The Ras-MAPK Signal Transduction Pathway

    By Jack D. Thatcher

    Science Signaling27 Apr 2010 : tr1 Full AccessRestricted Access

    Animated lessons illustrate a canonical signaling pathway activated by various hormones and growth factors.

    • Abstract
    • Full Text
    • PDF

  • The cAMP Signal Transduction Pathway

    By Jack D. Thatcher

    Science Signaling27 Apr 2010 : tr2 Full AccessRestricted Access

    Animated lessons illustrate cAMP signaling initiated by activation of G protein–coupled receptors.

    • Abstract
    • Full Text
    • PDF

  • The Inositol Trisphosphate (IP₃) Signal Transduction Pathway

    By Jack D. Thatcher

    Science Signaling27 Apr 2010 : tr3 Full AccessRestricted Access

    Animated lessons illustrate a signaling module that operates downstream of various hormones and growth factors.

    • Abstract
    • Full Text
    • PDF

  • The TGF-β Signal Transduction Pathway

    By Jack D. Thatcher

    Science Signaling27 Apr 2010 : tr4 Full AccessRestricted Access

    Animated lessons depict canonical TGF-β pathways.

    • Abstract
    • Full Text
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• Editors' Choice

  • Dimerization as a Drug Target

    By Wei Wong

    Science Signaling27 Apr 2010 : ec123 Full AccessRestricted Access

    The flavonol quercetin stabilizes the dimeric active form of the intracellular stress sensor IRE1.

    • Abstract

  • UPR to TLR Connection

    By Nancy R. Gough

    Science Signaling27 Apr 2010 : ec124 Full AccessRestricted Access

    Certain pathogen-sensing receptors activate one arm of the unfolded protein response to maximize transcriptional activation of inflammatory genes.

    • Abstract

  • Processing by Caspases

    By John F. Foley

    Science Signaling27 Apr 2010 : ec125 Full AccessRestricted Access

    Caspases in infected cells contribute to the presentation of viral peptides to cytotoxic T cells.

    • Abstract

  • Tumor Suppression Through Metabolic Regulation

    By Nancy R. Gough

    Science Signaling27 Apr 2010 : ec126 Full AccessRestricted Access

    By inducing the expression and activity of a mitochondrial glutaminase, p53 limits reactive oxygen species production and maintains oxidative respiration.

    • Abstract

  • How the Fruit Fly Got His Spots

    By Elizabeth M. Adler

    Science Signaling27 Apr 2010 : ec127 Full AccessRestricted Access

    Wingless determines the pattern of fruit fly wing pigmentation.

    • Abstract