Contents
Vol 3, Issue 119
Contents
Editorial Guide
- Focus Issue: Teaching Tools and Learning Opportunities
Science Signaling provides authoring experience for students and resources for educators.
Research Articles
- Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy
A volatile metabolic by-product can promote cell survival through the induction of autophagy.
- SUMOylation of the Transcriptional Co-Repressor KAP1 Is Regulated by the Serine and Threonine Phosphatase PP1
Two isoforms of protein phosphatase 1 coordinate the recovery of cells from genotoxic stress.
- Evolution of CASK into a Mg2+-Sensitive Kinase
The atypical kinase CASK evolved from a conventional Mg2+-dependent kinase.
Journal Club
- Costimulatory Role of CXCR4 with Pre-TCR and Its Crosstalk with PI3K in β-Selection of Thymocytes
Chemokine and pre-TCR signaling cooperate in β-selection of thymocytes and promote their subsequent proliferation.
- New Regulator for Energy Signaling Pathway in Plants Highlights Conservation Among Species
The kinase CIPK links plant pathways involved in oxygen-sensing and carbohydrate metabolism.
Teaching Resources
- The Ras-MAPK Signal Transduction Pathway
Animated lessons illustrate a canonical signaling pathway activated by various hormones and growth factors.
- The cAMP Signal Transduction Pathway
Animated lessons illustrate cAMP signaling initiated by activation of G protein–coupled receptors.
- The Inositol Trisphosphate (IP3) Signal Transduction Pathway
Animated lessons illustrate a signaling module that operates downstream of various hormones and growth factors.
- The TGF-β Signal Transduction Pathway
Animated lessons depict canonical TGF-β pathways.
Editors' Choice
- Dimerization as a Drug Target
The flavonol quercetin stabilizes the dimeric active form of the intracellular stress sensor IRE1.
- UPR to TLR Connection
Certain pathogen-sensing receptors activate one arm of the unfolded protein response to maximize transcriptional activation of inflammatory genes.
- Processing by Caspases
Caspases in infected cells contribute to the presentation of viral peptides to cytotoxic T cells.
- Tumor Suppression Through Metabolic Regulation
By inducing the expression and activity of a mitochondrial glutaminase, p53 limits reactive oxygen species production and maintains oxidative respiration.
- How the Fruit Fly Got His Spots
Wingless determines the pattern of fruit fly wing pigmentation.
