Contents
Vol 3, Issue 120
Contents
Research Articles
- Loops Govern SH2 Domain Specificity by Controlling Access to Binding Pockets
Selective blocking of binding pockets by surface loops defines the specificity of a phosphotyrosine-binding domain.
- In Vivo Identification of Regulators of Cell Invasion Across Basement Membranes
A Caenorhabditis elegans screen provides insight into cell invasion and metastasis.
Perspective
- "Complementing" Toll Signaling
A common oral pathogen uses the C5a receptor to selectively inhibit some TLR2 responses.
Podcast
- Science Signaling Podcast: 4 May 2010
Ammonia induces autophagy, which may help cancer cells survive stressful conditions.
Editors' Choice
- Anxiety, Recruited from Within
Corticotrophin-releasing factor (CRF) signaling through CRFR1 recruits serotonin receptors to the cell surface, thereby enhancing anxiety-related behaviors.
- Crystalline Danger Signal
Cholesterol crystals form in early atherosclerotic lesions and activate inflammatory responses.
- An ATPase for a Kinase
By promoting an inhibitory autophosphorylation event, the ATPase XP24 decreases immune responses mediated by the XA21 pattern recognition receptor.
- Adaptable G Protein
Gαq acts as a scaffold protein to assemble activators of the mitogen-activated protein kinase ERK5.
- TAZ, Jack of All Trades
The multifunctional protein TAZ links developmental signaling pathways and is implicated in kidney disease.
- Rethinking “Pseudo”
ErbB3, long thought to be a pseudokinase, exhibits catalytic activity in vitro.
- Biofilm Today, Gone Tomorrow
Bacteria secrete an unusual form of amino acids to escape from aging communities by dissolving the surrounding matrix.
- Signal to Slow Down
By bringing the Rap1 effector RapL to the membrane, the adaptor SKAP1 promotes adhesion, allowing activated T cell receptors to decrease T cell motility.
- The Adiponectin-Mitochondria Connection
Adiponectin signaling through AdipoR1 plays a crucial role in regulating muscle mitochondrial function.
- Light Structures
Fleeting molecular events are observed as light illuminates chlorophyll to initiate photosynthesis.
