04 May 2010
Vol 3, Issue 120
  • Contents

    • Research Articles

    • Perspective

    • Podcast

    • Editors' Choice

      • Anxiety, Recruited from Within

        Corticotrophin-releasing factor (CRF) signaling through CRFR1 recruits serotonin receptors to the cell surface, thereby enhancing anxiety-related behaviors.

      • Crystalline Danger Signal

        Cholesterol crystals form in early atherosclerotic lesions and activate inflammatory responses.

      • An ATPase for a Kinase

        By promoting an inhibitory autophosphorylation event, the ATPase XP24 decreases immune responses mediated by the XA21 pattern recognition receptor.

      • Adaptable G Protein

        q acts as a scaffold protein to assemble activators of the mitogen-activated protein kinase ERK5.

      • TAZ, Jack of All Trades

        The multifunctional protein TAZ links developmental signaling pathways and is implicated in kidney disease.

      • Rethinking “Pseudo”

        ErbB3, long thought to be a pseudokinase, exhibits catalytic activity in vitro.

      • Biofilm Today, Gone Tomorrow

        Bacteria secrete an unusual form of amino acids to escape from aging communities by dissolving the surrounding matrix.

      • Signal to Slow Down

        By bringing the Rap1 effector RapL to the membrane, the adaptor SKAP1 promotes adhesion, allowing activated T cell receptors to decrease T cell motility.

      • The Adiponectin-Mitochondria Connection

        Adiponectin signaling through AdipoR1 plays a crucial role in regulating muscle mitochondrial function.

      • Light Structures

        Fleeting molecular events are observed as light illuminates chlorophyll to initiate photosynthesis.

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article that identified genes encoding factors that promote cell invasion across basement membranes, a process that occurs during development, inflammatory responses, and cancer metastasis. The image is a composite time series showing a cell (green) breaching a basement membrane (purple). [Image: David Q. Matus, Biology Department, Duke University]