Contents
Vol 3, Issue 121
Contents
Research Articles
- Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse
Vesicles dynamically deliver the T cell adaptor protein LAT to sites of T cell signalosomes.
- Gβγ Activates GSK3 to Promote LRP6-Mediated β-Catenin Transcriptional Activity
A Xenopus reconstitution system reveals that the G protein Gβγ subunit contributes to β-catenin stabilization.
Perspective
- T Cell Activation at the Immunological Synapse: Vesicles Emerge for LATer Signaling
Subsynaptic vesicles that contain the adaptor protein linker of activated T cells regulate T cell signaling.
Podcast
- Science Signaling Podcast: 11 May 2010
Genes that affect development of the nematode gonad are implicated in cell invasion and metastasis.
Editors' Choice
- Maintaining Copper Supplies
Cardiac copper deficiency elicits a circulating signal that leads to an increase in circulating copper and in the abundance of a copper transporter in liver and intestine.
- Preventing Vitamin Overdoses?
Dietary absorption of vitamins A and D decreases bile acid synthesis through nuclear receptor–mediated transcriptional regulation.
- Wnt Signaling Heterogeneity
The tumor microenvironment controls the intensity of cancer-associated Wnt signaling.
- Tolerating Tumors
An immunotolerant microenvironment driven by chemokine expression contributes to tumor growth and spread.
- Keeping Balance in the Innate Immune System
A receptor protein helps avoid excessive activation of immune responses to invading pathogens.
- Exclusive States
Time-lapse microscopy reveals how Notch integrates signals from Delta molecules on the same cell with those from a neighboring cell.
- A Trick of the Tail
A synaptic vesicle protein must be membrane-anchored to stimulate fusion in vitro at physiological Ca2+ concentrations.
- Dangerous Dengue Provocation
Variable maturation of a dengue viral antigen results in incomplete neutralization and promotes secondary pathology.
- Taking It Slow
The time delay in transcriptional regulatory systems sets important constraints on biological control systems.
Errata
