Contents
Vol 3, Issue 122
Contents
Research Articles
- TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1
The inositol phosphatase SHIP1 binds to a receptor-adaptor complex on osteoclasts to prevent recruitment of PI3K and inhibit receptor signaling.
- c-mip Impairs Podocyte Proximal Signaling and Induces Heavy Proteinuria
Overexpression of the protein c-mip in mice produces phenotypes similar to various idiopathic kidney disorders.
Perspective
- Gyrate: CCM3 Dances with a Different Angiogenic Partner
CCM3 is a key regulator of a major signaling pathway involved in vascular development.
Editors' Choice
- Lending a Helping Hand
The functional diversity of GABAB receptor responses is endowed by tetrameric KCTD proteins that are part of the receptor complex.
- Systemic Nodulation Regulation
Peptide signals of the CLE family provide both local and systemic regulation of plant-bacteria symbiosis.
- siRNA Movement in Plant Tissues
Small double-stranded interfering RNAs move between cells and can direct DNA methylation.
- It's a Knockout
A calcium-dependent protein kinase is essential for blood-stage proliferation of the human malaria parasite.
- Fueling the Cancer Cell
Altered metabolic needs of cancer cells may provide a means to selectively inhibit their growth.
- Counting Na+ Channels One by One
Freeze fracture methods allow a numerical estimate of Na+ channel density in different compartments of CA1 pyramidal cells.
