Contents
Vol 3, Issue 123
Contents
Research Articles
- The Balance of WNT and FGF Signaling Influences Mesenchymal Stem Cell Fate During Skeletal Development
Imbalance of WNT and FGF signaling promotes premature closure of skull bones by inducing bone formation through chondrogenesis.
- Negative Feedback in Noncanonical NF-κB Signaling Modulates NIK Stability Through IKKα-Mediated Phosphorylation
Feedback inhibition of the central regulator of noncanonical NF-κB signaling is mediated by its target kinase.
- TRAF6 and A20 Regulate Lysine 63–Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy
Regulation of the ubiquitination of Beclin-1 may be a general mechanism that controls autophagy.
Perspective
- Controlling the Fate of NIK: A Central Stage in Noncanonical NF-κB Signaling
A component of the IκB kinase complex mediates feedback inhibition of the kinase NIK.
Podcast
- Science Signaling Podcast: 25 May 2010
The balance between WNT and FGF signaling influences the mode of bone formation in the skull.
Editors' Choice
- Uses the Force
Coupling to antigen-presenting cells through the T cell receptor renders T cells sensitive to mechanical force.
- Cytosol, Salmonella, and pH
Intravacuolar Salmonella sense host cytosolic pH, resulting in degradation of a regulatory complex and effector translocation.
- Escaping the Dephosphorylation Zone
Generation of signals crucial to arterial morphogenesis depends on VEGFR2 trafficking mechanisms that limit its exposure to the phosphatase PTP1b.
- All Together Now
Stochastic pulsing of individual cells plays a critical role in initiating cAMP pulses.
- Budding Yeast Kinome Revealed
Phosphorylation reactions in budding yeast reveal the regulatory architecture of a fundamental cellular control system.
- Evolving Bacteria and Computers
A bacterial regulatory network is compared to a computer operating system.
Errata
