Contents
Vol 3, Issue 124
Contents
Research Articles
- EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors
Some cancers showed decreased abundance of a subset of EGF-regulated microRNAs, which allows the production of oncogenic transcription factors.
- Transient ATM Kinase Inhibition Disrupts DNA Damage–Induced Sister Chromatid Exchange
Radiation triggers distinct responses in cells in which the kinase ATM is transiently inhibited versus those that have adapted to its loss.
Perspective
- Ammonia: A Diffusible Factor Released by Proliferating Cells That Induces Autophagy
A volatile metabolic by-product can induce autophagy in an autocrine and paracrine fashion.
Editors' Choice
- No Transcription Required
The transcription factor IRF-3 acts at the mitochondria to trigger apoptosis of virally infected cells.
- Paradoxical Signaling
The death receptor CD95 (Fas) is required for the growth of tumor cells.
- Proliferation Control
Control of cell proliferation and control of cell size are separately regulated in mammals.
- Fat-Burning Fat
In mice, the development of energy-burning brown fat is regulated by an enzyme that is critical for prostaglandin synthesis.
- Thymocyte Egress
Cells that ensheath blood vessels promote exit of the developing T lymphocytes from the thymus.
- Defining Defensins’ Mode of Action
Some metazoan and fungal host defense peptides are specific inhibitors of bacterial peptidoglycan biosynthesis.
