Contents
Vol 3, Issue 125
Contents
Research Articles
- Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation
Neutrophil activation by infectious and inflammatory signals requires ATP release and its feedback through purinergic receptors.
- β-Arrestin–Biased Agonism of the Angiotensin Receptor Induced by Mechanical Stress
Mechanical stress on hearts triggers β-arrestin–dependent cell survival signaling through the angiotensin receptor.
Perspective
- Eradicating the Mediators of Neuronal Death with a Fine-Tooth Comb
Polycomb group proteins promote the acquisition of ischemic tolerance in neurons.
Podcast
- Science Signaling Podcast: 8 June 2010
Mechanical stimulation of the angiotensin receptor promotes cell survival by preferentially activating β-arrestin–dependent signaling.
Editors' Choice
- Forced to Signal
A mechanism is revealed for cells to convert a mechanical signal into a biochemical one.
- Protection from Afar
A factor secreted from anterior neurons in Caenorhabditis elegans protects germ cells from apoptosis.
- Germline Quality Control
A tumor suppressor appears to protect against aberrant chromosome breakage during meiosis.
- Depressed About Caspases?
Elements of the mitochondrial apoptosis pathway are used to mediate long-term depression of synaptic function.
- pH Signaling Through Arrestin
Ubiquitylation of a fungal arrestin is sufficient to activate signaling.
- Pharmacological Forgetting
Pharmacological agents can be used to treat disorders of pathological fear without reactivating the original memory trace.
- Keeping Tabs on Second-Messenger Localization
Genetically encoded biosensors visualize the dynamics of a global signaling molecule within bacterial cells.
- Initiator for Coated Pit Assembly
Membrane-sculpting proteins nucleate clathrin-coated pits during endocytosis.
- Sepsis Protection
Blockade of an enzyme that promotes inflammation results in protection from lethal sepsis.
- Making Menorahs
In developing Caenorhabditis elegans during neuronal arborization, excess neurite branches are retracted and fuse.
- Rewiring for Longer Life
An expanded role in promoting longevity is defined for a signaling protein in the unfolded protein response pathway.
