08 June 2010
Vol 3, Issue 125
  • Contents

    • Research Articles

    • Perspective

    • Podcast

      • Science Signaling Podcast: 8 June 2010

        Mechanical stimulation of the angiotensin receptor promotes cell survival by preferentially activating β-arrestin–dependent signaling.

    • Editors' Choice

      • Forced to Signal

        A mechanism is revealed for cells to convert a mechanical signal into a biochemical one.

      • Protection from Afar

        A factor secreted from anterior neurons in Caenorhabditis elegans protects germ cells from apoptosis.

      • Germline Quality Control

        A tumor suppressor appears to protect against aberrant chromosome breakage during meiosis.

      • Depressed About Caspases?

        Elements of the mitochondrial apoptosis pathway are used to mediate long-term depression of synaptic function.

      • pH Signaling Through Arrestin

        Ubiquitylation of a fungal arrestin is sufficient to activate signaling.

      • Pharmacological Forgetting

        Pharmacological agents can be used to treat disorders of pathological fear without reactivating the original memory trace.

      • Sepsis Protection

        Blockade of an enzyme that promotes inflammation results in protection from lethal sepsis.

      • Making Menorahs

        In developing Caenorhabditis elegans during neuronal arborization, excess neurite branches are retracted and fuse.

      • Rewiring for Longer Life

        An expanded role in promoting longevity is defined for a signaling protein in the unfolded protein response pathway.

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article describing how mechanical stress on hearts triggers ligand-independent, β-arrestin–dependent signaling through the angiotensin receptor to promote cell survival. [Image:]