Contents
Vol 3, Issue 126
Contents
Research Article
- Ablation of the Kinase NDR1 Predisposes Mice to the Development of T Cell Lymphoma
The kinase NDR1 functions as a haploinsufficient tumor suppressor by ensuring proper apoptotic responses.
Protocol
- Analysis of Matrix-Dependent Cell Migration with a Barrier Migration Assay
Removable plastic barriers allow quantification of cell migration without damaging either the surface proteins or the cells.
Editors' Choice
- Even Flies Have Cravings
Mated fruit flies eat more protein in response to a peptide in male fly seminal fluid.
- Taking AIM at Adipocytes
The macrophage-derived protein AIM is taken up by adipocytes and induces a reduction in adipose tissue mass.
- NOCing PPAR-γ into the Nucleus?
Nocturnin promotes the nuclear translocation of PPAR-γ2 and thereby adipogenesis.
- Toxic Clusters
Forced clustering of metabotropic glutamate receptors by β-amyloid oligomers causes increased calcium influx.
- Platelet NF-κB–PKA Complex
Platelet aggregation is kept in check by inhibitory signaling from protein kinase A released from the IKK (inhibitor of nuclear factor κB kinase) complex.
- Too Much of a Good Thing
To prevent too much myelin from causing trouble, two proteins act to limit insulation of axons.
- Seeing EPO
Modeling and experiments help explain responsiveness of red blood cell precursors to very large changes in a proliferative signal.
