15 June 2010
Vol 3, Issue 126
  • Contents

    • Research Article

    • Protocol

    • Editors' Choice

      • Even Flies Have Cravings

        Mated fruit flies eat more protein in response to a peptide in male fly seminal fluid.

      • Taking AIM at Adipocytes

        The macrophage-derived protein AIM is taken up by adipocytes and induces a reduction in adipose tissue mass.

      • NOCing PPAR-γ into the Nucleus?

        Nocturnin promotes the nuclear translocation of PPAR-γ2 and thereby adipogenesis.

      • Toxic Clusters

        Forced clustering of metabotropic glutamate receptors by β-amyloid oligomers causes increased calcium influx.

      • Platelet NF-κB–PKA Complex

        Platelet aggregation is kept in check by inhibitory signaling from protein kinase A released from the IKK (inhibitor of nuclear factor κB kinase) complex.

      • Too Much of a Good Thing

        To prevent too much myelin from causing trouble, two proteins act to limit insulation of axons.

      • Seeing EPO

        Modeling and experiments help explain responsiveness of red blood cell precursors to very large changes in a proliferative signal.

About The Cover

Cover image expansion

Online Cover This week's issue features a Protocol describing how to construct and use removable plastic barriers to quantify cell migration without damaging either the surface proteins or the cells. The image shows HKC-8 cells migrating into a gap on a fibronectin-coated surface. [Image: Sven Kroening, Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany]