Contents
Vol 3, Issue 127
Contents
Editorial Guide
- (R)evolution of Complex Regulatory Systems
Understanding the implications of the changes in signaling systems requires analysis in both cellular and evolutionary time scales.
Research Article
- Nodal Signaling Recruits the Histone Demethylase Jmjd3 to Counteract Polycomb-Mediated Repression at Target Genes
Developmental signaling integrates with epigenetic processes to control the expression of Nodal target genes.
Perspectives
- Wnt Signaling in Axial Patterning and Regeneration: Lessons from Planaria
Positional information generated by Wnt signaling determines whether heads or tails will form in wounded flatworms.
- Infrared Snake Eyes: TRPA1 and the Thermal Sensitivity of the Snake Pit Organ
Many vertebrates and invertebrates rely on the ion channel TRPA1 to detect both warmth and chemicals.
Editors' Choice
- Competing for Transport
Competition between nitrate and auxin for binding to the nitrate transporter protein NRT1.1 regulates the growth of lateral roots in plants.
- Bistable Trypanosome Switch
A glycosome-associated switch regulates transition of trypanosomes from host- to vector-specific forms.
- Preventing Spasms After Spinal Cord Injury
Following spinal cord injury, motoneurons switch to a constitutively active serotonin receptor, which contributes to muscle spasticity.
- A Postreceptor Intervention
Modulation of 5-HT1A receptor–associated Gαi2 activity has antidepressant-like effects in mice.
- MiR-33 in Cholesterol Control
A small noncoding RNA helps regulate cholesterol levels in mice.
- Herpes Virus MiRNA Modulation
A viral noncoding RNA regulates the level of a complementary host cell’s microRNA.
