29 June 2010
Vol 3, Issue 128
  • Contents

    • Editorial Guide

    • Research Articles

    • Perspective

    • Podcast

    • Editors' Choice

      • Making Yeast Horny

        Switching to sexual reproduction requires a specific phosphorylation of RNA polymerase II at the master regulator gene ste11.

      • Rallying the Commensal Troops

        Engineering commensal bacteria to signal to Vibrio cholerae could provide an approach to cholera prophylaxis.

      • A Gut Feeling

        Immunoglobulin responses against nonpathogenic bacteria in the gut are specific for the resident microbial flora.

      • Inhibiting Leukocytosis

        Pathways that reduce cholesterol in atherosclerosis also suppress increased immune cell numbers associated with the disease.

      • Kuz-Cleaved Robo Repels

        Proteolytic cleavage of the receptor Robo is required for axonal repulsion in Drosophila.

      • Acid and Alzheimer’s

        Mutations in presenilin 1 associated with familial Alzheimer’s disease prevent acidification of lysosomes and block autophagy.

      • Aggregator of the Regulator

        In addition to oxidative stress, the transcription factor Nrf2 can also be activated by impaired autophagy.

      • Bacterial (Interferon)ce

        Within the host cell, a small secondary signaling molecule from a pathogen triggers a pathway of innate immunity.

      • Addicts Lose Plasticity

        Loss of glutamate receptor–dependent synaptic plasticity in the brain is associated with the transition to cocaine addiction.

About The Cover

Cover image expansion

Online Cover This week features the second issue in the series about the evolution of signaling molecules and networks. The Editorial Guide includes examples of how analysis of molecule and network evolution is revealing insights for protein engineering, uncovering previously unknown signaling intermediates, and even guiding thoughts about speciation. The cover image is a phyletic analysis of bacteria chemotaxis systems. [Image: Kristin Wuichet, BioEnergy Science Center and Computer Science and Mathematics Division, Oak Ridge National Laboratory, and Department of Microbiology, University of Tennessee, TN ]