06 July 2010
Vol 3, Issue 129
  • Contents

    • Research Article

    • Meeting Report

    • Podcast

    • Editors' Choice

      • Decoyed from Tumorigenesis

        A PTEN pseudogene generates a microRNA decoy that acts as a tumor suppressor.

      • Move or Divide?

        A nonreceptor guanine nucleotide exchange factor for Gαi interacts with EGFR to tip cells from proliferating to migrating.

      • Squeezing Through with Sema3A

        Sema3A activates ROCK- and myosin-dependent contraction to promote dendritic cell entry into the lymphatics.

      • One Two T

        A transcription factor is essential for maintenance of T cell identity.

      • "Dangerous" Hair

        A genome-wide association study reveals that ligands that serve as danger signals are overproduced in hair follicles of patients with a disfiguring form of hair loss.

      • No Genetic Vertigo

        Sequencing coding regions identified genetic changes likely involved in adaptation to hypoxia.

      • Can Rho Regulate Its Regulator?

        The crystal structure of an exchange factor fragment with a small GTPase reveals potential for complex regulatory interactions.

About The Cover

Cover image expansion

Online Cover This week features a Research Article describing a mathematical model that explains how errors are minimized in the specification of cells that form sensory bristles on flies. The analysis revealed that accurate selection of bristle-forming sensory organ precursor cells in fruit flies requires cell-autonomous Notch-ligand interactions to prevent inappropriate fate specification in neighboring cells. The cover image shows a fly with extra bristles due to an error in the fate specification of the sensory organ precursor cells. [Image: Omer Barad, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel]