Contents
Vol 3, Issue 132
Contents
Research Articles
- Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis
Amplification of outside-in chemotactic signaling by inside-out purinergic signaling drives macrophage migration.
- Decoupling of Receptor and Downstream Signals in the Akt Pathway by Its Low-Pass Filter Characteristics
The Akt pathway can serve as a signal decoupler, converting a weak receptor signal into a strong effector signal.
- The Drosophila Female Germline Stem Cell Lineage Acts to Spatially Restrict DPP Function Within the Niche
Drosophila ovarian stem cells communicate with somatic cells to define the size of the stem cell niche.
Perspective
- Inhibiting the Inhibitor of the Inhibitor: Blocking PKC-θ to Enhance Regulatory T Cell Function
PKC-θ functions differently in regulatory T cells, which may be linked to its exclusion from immune synapses.
Editors' Choice
- Estrogen Receptor Versatility
The estrogen receptor β functions with and without its estrogen ligand.
- Local Caspase for Fertility, Not Death
Through gradients of inhibitors, fly spermatids control caspase activation to promote differentiation without death.
- A Phosphorylation Target for Diabetes Therapy
PPARγ ligand drugs exert their antidiabetic effect by blocking the phosphorylation of PPARγ by Cdk5.
- Brain over Muscle
Identification of the origin of muscle weakness that accompanies a form of neonatal diabetes may lead to safer therapies.
- Fat’s Mixed Messages
Fat cells secrete an anti-inflammatory factor that has beneficial effects on metabolic health.
- Inhibition by Integrin
Inside-out activation of the β2 integrin subunit CD11b inhibits Toll-like receptor signaling in macrophages.
- TOR Inhibition Promotes Self-Renewal
The TSC1-TSC2 complex represses differentiation of germline stem cells in Drosophila.
- Let There Be Light
A bacterial ion pump rescues visual function in damaged cone-photoreceptor cells in mouse models of retinitis pigmentosa.
- Staying in Place
Signaling proteins are retained in the cilium by a diffusion barrier created by a member of the septin family.
- Making the Final Cut
Network modeling reveals an RNA splicing network in the brain and uncovers complex mechanisms of regulation.
- Endocytotic Notch Signal
Low-density lipoprotein receptor–related protein-1 promotes endocytosis that influences non–cell autonomous Notch signaling.
