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Research ArticleCOMPUTATIONAL BIOLOGY
Decoupling of Receptor and Downstream Signals in the Akt Pathway by Its Low-Pass Filter Characteristics
- Kazuhiro A. Fujita1,
- Yu Toyoshima2,
- Shinsuke Uda2,
- Yu-ichi Ozaki2,
- Hiroyuki Kubota2, and
- Shinya Kuroda1,2,*
- 1Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, Kshiwanoha 5-1-5, Kashiwa, Chiba 277-8568, Japan.
- 2Department of Biophysics and Biochemistry, Graduate School of Science, CREST, Japan Science and Technology Agency, University of Tokyo, Hongo 7-3-1, Bunkyo-ku,Tokyo 113-0033, Japan.
- ↵*To whom correspondence should be addressed. E-mail: skuroda{at}bi.s.u-tokyo.ac.jp
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Science Signaling 27 Jul 2010:
Vol. 3, Issue 132, pp. ra56
DOI: 10.1126/scisignal.2000810
Vol. 3, Issue 132, pp. ra56
DOI: 10.1126/scisignal.2000810
Kazuhiro A. Fujita
1Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, Kshiwanoha 5-1-5, Kashiwa, Chiba 277-8568, Japan.
Yu Toyoshima
2Department of Biophysics and Biochemistry, Graduate School of Science, CREST, Japan Science and Technology Agency, University of Tokyo, Hongo 7-3-1, Bunkyo-ku,Tokyo 113-0033, Japan.
Shinsuke Uda
2Department of Biophysics and Biochemistry, Graduate School of Science, CREST, Japan Science and Technology Agency, University of Tokyo, Hongo 7-3-1, Bunkyo-ku,Tokyo 113-0033, Japan.
Yu-ichi Ozaki
2Department of Biophysics and Biochemistry, Graduate School of Science, CREST, Japan Science and Technology Agency, University of Tokyo, Hongo 7-3-1, Bunkyo-ku,Tokyo 113-0033, Japan.
Hiroyuki Kubota
2Department of Biophysics and Biochemistry, Graduate School of Science, CREST, Japan Science and Technology Agency, University of Tokyo, Hongo 7-3-1, Bunkyo-ku,Tokyo 113-0033, Japan.
Shinya Kuroda
1Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, Kshiwanoha 5-1-5, Kashiwa, Chiba 277-8568, Japan.
2Department of Biophysics and Biochemistry, Graduate School of Science, CREST, Japan Science and Technology Agency, University of Tokyo, Hongo 7-3-1, Bunkyo-ku,Tokyo 113-0033, Japan.
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