The Nonphagocytic NADPH Oxidase Duox1 Mediates a Positive Feedback Loop During T Cell Receptor Signaling

Jaeyul Kwon; Kristen E. Shatynski; Haiyan Chen; Stanislas Morand; Xavier de Deken; Françoise Miot; Thomas L. Leto; Mark S. Williams

doi:10.1126/scisignal.2000976

Research ArticleImmunology

The Nonphagocytic NADPH Oxidase Duox1 Mediates a Positive Feedback Loop During T Cell Receptor Signaling

Jaeyul Kwon¹,²,*,
Kristen E. Shatynski¹,
Haiyan Chen¹,
Stanislas Morand²,
Xavier de Deken³,
Françoise Miot³,
Thomas L. Leto², and
Mark S. Williams¹,*

¹Center for Vascular and Inflammatory Diseases, Department of Microbiology and Immunology, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA.
²Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA.
³Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Université Libre de Bruxelles, Campus Erasme, 1070 Brussels, Belgium.

↵*To whom correspondence should be addressed. E-mail: marwilliams{at}som.umaryland.edu (M.S.W.); kwonja{at}niaid.nih.gov (J.K.)

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Science Signaling 03 Aug 2010:
Vol. 3, Issue 133, pp. ra59
DOI: 10.1126/scisignal.2000976

Jaeyul Kwon

1Center for Vascular and Inflammatory Diseases, Department of Microbiology and Immunology, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA.

2Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA.

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For correspondence: marwilliams@som.umaryland.edu kwonja@niaid.nih.gov

Kristen E. Shatynski

1Center for Vascular and Inflammatory Diseases, Department of Microbiology and Immunology, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA.

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Haiyan Chen

1Center for Vascular and Inflammatory Diseases, Department of Microbiology and Immunology, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA.

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Stanislas Morand

2Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA.

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Xavier de Deken

3Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Université Libre de Bruxelles, Campus Erasme, 1070 Brussels, Belgium.

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Françoise Miot

3Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Université Libre de Bruxelles, Campus Erasme, 1070 Brussels, Belgium.

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Thomas L. Leto

2Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA.

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Mark S. Williams

1Center for Vascular and Inflammatory Diseases, Department of Microbiology and Immunology, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA.

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For correspondence: marwilliams@som.umaryland.edu kwonja@niaid.nih.gov

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The Nonphagocytic NADPH Oxidase Duox1 Mediates a Positive Feedback Loop During T Cell Receptor Signaling

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