Contents
Vol 3, Issue 134
Contents
Research Article
- The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development
Different isoforms of phosphatidylinositol 3-kinase have distinct roles in B cell receptor signaling.
Perspectives
- B Cell Receptor Signaling: Picky About PI3Ks
The p110α isoform of class IA phosphatidylinositol 3-kinases has a selective function in tonic B cell receptor signaling.
- Trafficking, Acidification, and Growth Factor Signaling
Activation of Wnt and Notch pathways requires endocytosis of receptor complexes to an acidified vesicular compartment.
Editors' Choice
- Extended Influence
The mammalian target of rapamycin complex 1 (mTORC1) stimulates metabolic pathways that include glycolysis and lipid biosynthesis.
- Degraded but not Dishevelled
Degradation of the scaffold protein Dishevelled by autophagy inhibits Wnt signaling.
- Limiting Lesions
Depletion of mature B cells is protective against atherosclerosis in mouse models.
- Muscle Building with Myc-Nick
A cleaved form of Myc acts in the cytoplasm to regulate microtubule dynamics and contributes to muscle cell differentiation.
- Fanconi Anemia Protein in DNA Binding
The nuclease FAN1 acts with Fanconi anemia proteins to help repair damaged DNA.
Erratum
- A Correction to the Research Article Titled: "Inferring Signaling Pathway Topologies from Multiple Perturbation Measurements of Specific Biochemical Species" by T.-R. Xu, V. Vyshemirsky, A. Gormand, A. von Kriegsheim, M. Girolami, G. S. Baillie, D. Ketley, A. J. Dunlop, G. Milligan, M. D. Houslay, W. Kolch
The authors acknowledge an additional source of funding.
