Research ArticleImmunology The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development Faruk Ramadani1, Daniel J. Bolland2, Fabien Garcon1, Juliet L. Emery1, Bart Vanhaesebroeck3, Anne E. Corcoran2, and Klaus Okkenhaug1,*1Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK.2Chromatin and Gene Expression, Babraham Institute, Cambridge CB22 3AT, UK.3Centre for Cell Signaling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.↵*To whom correspondence should be addressed. E-mail: klaus.okkenhaug{at}bbsrc.ac.uk See allHide authors and affiliations Science Signaling 10 Aug 2010:Vol. 3, Issue 134, pp. ra60DOI: 10.1126/scisignal.2001104 Faruk Ramadani 1Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Daniel J. Bolland 2Chromatin and Gene Expression, Babraham Institute, Cambridge CB22 3AT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Fabien Garcon 1Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Juliet L. Emery 1Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Bart Vanhaesebroeck 3Centre for Cell Signaling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Anne E. Corcoran 2Chromatin and Gene Expression, Babraham Institute, Cambridge CB22 3AT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Klaus Okkenhaug 1Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: klaus.okkenhaug@bbsrc.ac.uk Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 3 no. 134 ra60 DOI: https://doi.org/10.1126/scisignal.2001104 PubMed: 20699475 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received April 21, 2010Accepted July 23, 2010 . Copyright & Usage: Copyright © 2010, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: August 2010 to March 2021 AbstractFullPdf Aug 20101713203381 Sep 20102127476 Oct 20101955852 Nov 2010952426 Dec 2010822038 Jan 2011963135 Feb 2011894232 Mar 20111242774 Apr 2011942150 May 2011702131 Jun 2011861221 Jul 2011572219 Aug 2011511621 Sep 2011491121 Oct 2011891117 Nov 2011581117 Dec 2011411815 Jan 2012722423 Feb 201254919 Mar 2012831915 Apr 2012601416 May 2012661417 Jun 201232107 Jul 2012591420 Aug 2012711017 Sep 201266814 Oct 2012711313 Nov 2012601517 Dec 2012391810 Jan 2013761618 Feb 20131861812 Mar 2013502919 Apr 2013482314 May 201351165 Jun 2013391813 Jul 2013561512 Aug 2013361111 Sep 20134279 Oct 201353109 Nov 2013701515 Dec 2013831312 Jan 2014552010 Feb 2014581410 Mar 20145399 Apr 2014531113 May 2014741818 Jun 201489188 Jul 201474105 Aug 20144149 Sep 2014381815 Oct 201425118 Nov 20142838 Dec 2014281111 Jan 201521127 Feb 201591010 Mar 20152074 Apr 20152276 May 20153992 Jun 20155273 Jul 20152346 Aug 20157711 Sep 20156213 Oct 2015227 Nov 20151310 Dec 20151925 Jan 20166657 Feb 201661411 Mar 20165213 Apr 20165282 May 20163955 Jun 201611846 Jul 20166662 Aug 20164535 Sep 2016112016 Oct 20166804 Nov 20165804 Dec 20163014 Jan 20176148 Feb 20175049 Mar 20173803 Apr 20174828 May 20173936 Jun 20172514 Jul 201742410 Aug 20174936 Sep 201739210 Oct 20173176 Nov 20173823 Dec 20171612 Jan 20184365 Feb 20186035 Mar 20185744 Apr 20183558 May 20183825 Jun 20184254 Jul 20182934 Aug 201842217 Sep 2018312411 Oct 201839173 Nov 201826146 Dec 20183383 Jan 20193764 Feb 20193897 Mar 201933147 Apr 201918136 May 20192566 Jun 201934105 Jul 20192076 Aug 2019996 Sep 201915169 Oct 201935104 Nov 20192341 Dec 20193034 Jan 202024104 Feb 20203145 Mar 20201885 Apr 202020142 May 20202241 Jun 20202363 Jul 20202680 Aug 20207113 Sep 20201140 Oct 202017124 Nov 20204163 Dec 202025157 Jan 20211973 Feb 202119106 Mar 2021100 View Full Text
The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development By Faruk Ramadani, Daniel J. Bolland, Fabien Garcon, Juliet L. Emery, Bart Vanhaesebroeck, Anne E. Corcoran, Klaus Okkenhaug Science Signaling10 Aug 2010 : ra60 Different isoforms of phosphatidylinositol 3-kinase have distinct roles in B cell receptor signaling.
The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development By Faruk Ramadani, Daniel J. Bolland, Fabien Garcon, Juliet L. Emery, Bart Vanhaesebroeck, Anne E. Corcoran, Klaus Okkenhaug Science Signaling10 Aug 2010 : ra60 Different isoforms of phosphatidylinositol 3-kinase have distinct roles in B cell receptor signaling.