Research ArticleDevelopmental Biology Self-Induced Patched Receptor Down-Regulation Modulates Cell Sensitivity to the Hedgehog Morphogen Gradient Andreu Casali*Institut de Biologia Molecular de Barcelona and Institute for Research in Biomedicine, Carrer Baldiri Reixach 10, 08028 Barcelona, Spain.↵*To whom correspondence should be addressed. E-mail: actbmc{at}ibmb.csic.es See allHide authors and affiliations Science Signaling 24 Aug 2010:Vol. 3, Issue 136, pp. ra63DOI: 10.1126/scisignal.2001059 Andreu Casali Institut de Biologia Molecular de Barcelona and Institute for Research in Biomedicine, Carrer Baldiri Reixach 10, 08028 Barcelona, Spain.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: actbmc@ibmb.csic.es Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 3 no. 136 ra63 DOI: https://doi.org/10.1126/scisignal.2001059 PubMed: 20736483 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received April 5, 2010Accepted August 6, 2010 . Copyright & Usage: Copyright © 2010, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: August 2010 to February 2021 AbstractFullPdf Aug 20101328187233 Sep 20102483898 Oct 2010801136 Nov 201041521 Dec 201052512 Jan 201161912 Feb 20114764 Mar 20114763 Apr 201150311 May 20115497 Jun 201150915 Jul 201172813 Aug 20114679 Sep 20119157 Oct 20113815 Nov 201173910 Dec 20114264 Jan 20123332 Feb 20123436 Mar 20124043 Apr 20122113 May 20123243 Jun 20122552 Jul 20121944 Aug 20122110 Sep 20122306 Oct 20122243 Nov 201220104 Dec 20125733 Jan 20133424 Feb 20133522 Mar 20132312 Apr 20131810 May 20131631 Jun 20132823 Jul 20133022 Aug 20133832 Sep 20132723 Oct 20132624 Nov 20133434 Dec 20135484 Jan 20143994 Feb 20141964 Mar 20142512 Apr 20141455 May 20143541 Jun 20143500 Jul 20143421 Aug 20145223 Sep 20141374 Oct 2014300 Nov 20141933 Dec 20143248 Jan 2015764 Feb 20151400 Mar 2015778 Apr 2015604 May 2015600 Jun 20152346 Jul 20152312 Aug 2015302 Sep 2015622 Oct 2015021 Nov 2015012 Dec 20151012 Jan 20164248 Feb 20162311 Mar 2016923 Apr 20162020 May 20161210 Jun 20164733 Jul 20164052 Aug 20164123 Sep 20163400 Oct 20163010 Nov 20162800 Dec 20162110 Jan 20172631 Feb 20173923 Mar 20176502 Apr 20177301 May 20174431 Jun 20175521 Jul 20178530 Aug 20179311 Sep 20175010 Oct 20173620 Nov 20175162 Dec 20175010 Jan 20185721 Feb 20185221 Mar 20185220 Apr 20186362 May 20183631 Jun 20182510 Jul 20181811 Aug 20181842 Sep 20181732 Oct 20181952 Nov 20182640 Dec 20182220 Jan 20192171 Feb 20191742 Mar 20191173 Apr 20191362 May 20191420 Jun 20191220 Jul 20191110 Aug 2019960 Sep 20191210 Oct 20191052 Nov 20191931 Dec 20192041 Jan 20201630 Feb 2020520 Mar 2020931 Apr 20201130 May 2020510 Jun 2020354 Jul 20202231 Aug 2020430 Sep 2020582 Oct 20201060 Nov 20201120 Dec 20201383 Jan 20212250 Feb 20211120 View Full Text
Self-Induced Patched Receptor Down-Regulation Modulates Cell Sensitivity to the Hedgehog Morphogen Gradient By Andreu Casali Science Signaling24 Aug 2010 : ra63 A self-regulating receptor allows cells to maintain the appropriate balance of ligand-bound and unbound receptors.
Self-Induced Patched Receptor Down-Regulation Modulates Cell Sensitivity to the Hedgehog Morphogen Gradient By Andreu Casali Science Signaling24 Aug 2010 : ra63 A self-regulating receptor allows cells to maintain the appropriate balance of ligand-bound and unbound receptors.