Contents
Vol 3, Issue 137
Contents
Editorial Guide
- Focus Issue: Systems Analysis of Protein Phosphorylation
Kinases and phosphatases are stars in the signaling universe.
Research Resources
- Comprehensive Expression Profiles of Genes for Protein Tyrosine Phosphatases in Immune Cells
Gene expression analysis suggests that protein tyrosine phosphatases exhibit immune cell–specific expression profiles.
- Collection and Motif-Based Prediction of Phosphorylation Sites in Human Viruses
A database of known phosphorylation sites on viral proteins also enables the prediction of other potential sites.
Protocol
- Targeting the Reversibly Oxidized Protein Tyrosine Phosphatase Superfamily
Mildly acidic pH and degassed buffers are the keys to successfully identifying redox-sensitive tyrosine phosphatases.
Editors' Choice
- As a Matter of Fak…
Focal adhesion kinase is required for intestinal tumorigenesis and regeneration but dispensable for homeostasis.
- Repressing Repressors to Make Memories
By inhibiting the production of a microRNA, the deacetylase SIRT1 and the transcriptional repressor YY1 allow memory formation.
- A DEETerrent Against Feeding
The insecticide DEET activates gustatory receptors to induce aversive responses in Drosophila.
- Plants’ Modified SOS Call
Damage caused by a caterpillar releases compounds that are transformed by the pest’s saliva into a predator attractant.
- Complex Inhibition
The Drosophila PP2A phosphatase complex dSTRIPAK dephosphorylates Hippo to inhibit Hippo signaling.
- Intracellular pH and Lipid Metabolism
Lipid signaling in yeast is regulated by intracellular pH.
