07 September 2010
Vol 3, Issue 138
  • Contents

    • Editorial Guide

      • Looking Ahead to the Past

        Chief Scientific Editor Michael Yaffe makes his predictions for exciting new areas of signaling-related research.

    • Perspective

      • NF-κB: Much Learned, Much to Learn

        The book NF-κB: A Network Hub Controlling Immunity, Inflammation, and Cancer provides an overview of various aspects of NF-κB signaling.

    • Journal Club

    • Editors' Choice

      • Stress-Induced Angiogenesis

        Blocking the activity of the stress sensor IRE1 reduces angiogenesis in gliomas.

      • Chaperoning mTORC1 Activity

        Chaperone availability regulates mTORC1 signaling, providing a link between protein quality control and translation.

      • Gene-Associated AMPK

        The energy sensor AMPK localizes to chromatin and phosphorylates histone H2B to facilitate gene transcription and cellular adaptation to stress.

      • Skin Reaction

        A costimulatory receptor for immune cells in the skin is identified.

      • Moving in 2D Versus 3D

        The actin-depolymerizing protein cofilin is required for T cell movement in a 3D environment but not a 2D one.

      • Gee-Up, NEDD8

        Pathogenic bacterial proteins interfere with eukaryotic ubiquitination pathways to induce cytopathic effects.

      • Here to Stay

        Bacterial colonization of the mucosa is facilitated if the microbes engage a human receptor that counteracts epithelial exfoliation.

About The Cover

Cover image expansion

Online Cover In this week's Editorial Guide, Chief Scientific Editor Michael Yaffe quotes the White Queen from Through the Looking-Glass regarding believing impossible things and makes predictions for three seemingly impossible things from the past that may emerge as exciting new areas of signaling research. The image is Alice and the White Queen by John Tenniel from Through the Looking-Glass by Charles Lutwidge Dodgson. [Image: John Tenniel]