Contents
Vol 3, Issue 139
Contents
Editorial Guide
- Focus Issue: Evolution III—Domains for Change
Domains provide evolution with tools for the creation of new functions.
Research Article
- Characterization of the Extrinsic Apoptotic Pathway in the Basal Chordate Amphioxus
Death domain–dependent signaling in the basal chordate amphioxus suggests that extrinsic apoptotic signaling is not restricted to vertebrates.
Perspectives
- Domain Recombination: A Workhorse for Evolutionary Innovation
Firm evidence for domain shuffling as a means of evolving new functions might lead us to the creation of combinations of practical benefit.
- Signals: Tinkering with Domains
Binding domains in signaling proteins can tolerate sequence variation but still bind ligands and be structurally stable.
Review
- ABL Tyrosine Kinases: Evolution of Function, Regulation, and Specificity
Insights from the regulation of ABL-family tyrosine kinases could facilitate development of therapies for malignancies driven by ABL fusion proteins.
Editors' Choice
- Autophagy for Inflammation
By limiting reactive oxygen species production, autophagy promotes cellular response to interferon γ.
- Opposing Inflammation and Thereby Diabetes
ω-3 fatty acids signal through GPR120 to reduce inflammation and promote insulin sensitivity.
- Amplifying Stem Cells
A purine derivative promotes expansion of multipotent hematopoietic stem cells by suppressing differentiation.
- TrkB or Not TrkB?
Distinct signaling properties of the TrkB neurotrophin receptor explain differential control of developmental cell death in the central and peripheral nervous systems.
- Combining Antibody Forces
Antibodies that promote phagocytosis through distinct mechanisms have synergistic effects against non-Hodgkin lymphoma.
- Form and Function
A gene involved in morphogenesis and ciliogenesis is mutated in patients with Bardet-Biedl syndrome.
- The Root of the Problem
Oscillations in gene expression define the positions of periodic lateral roots in a plant model.
- UnSIRT6ain Repair
A protein implicated in stress, aging, and genome stability is required for the accurate repair of broken DNA.
- Mosquito Malarial Memory
Early immune priming limits malaria parasite infection of mosquitoes.
