14 September 2010
Vol 3, Issue 139
  • Contents

    • Editorial Guide

    • Research Article

    • Perspectives

    • Review

    • Editors' Choice

      • Autophagy for Inflammation

        By limiting reactive oxygen species production, autophagy promotes cellular response to interferon γ.

      • Amplifying Stem Cells

        A purine derivative promotes expansion of multipotent hematopoietic stem cells by suppressing differentiation.

      • TrkB or Not TrkB?

        Distinct signaling properties of the TrkB neurotrophin receptor explain differential control of developmental cell death in the central and peripheral nervous systems.

      • Combining Antibody Forces

        Antibodies that promote phagocytosis through distinct mechanisms have synergistic effects against non-Hodgkin lymphoma.

      • Form and Function

        A gene involved in morphogenesis and ciliogenesis is mutated in patients with Bardet-Biedl syndrome.

      • The Root of the Problem

        Oscillations in gene expression define the positions of periodic lateral roots in a plant model.

      • UnSIRT6ain Repair

        A protein implicated in stress, aging, and genome stability is required for the accurate repair of broken DNA.

      • Mosquito Malarial Memory

        Early immune priming limits malaria parasite infection of mosquitoes.

About The Cover

Cover image expansion

Online Cover This week features the third issue in the series about the evolution of signaling molecules and networks. The Editorial Guide describes examples of how protein domains can serve as a medium for evolution. The image depicts how sequence variation enables a protein domain to acquire new ligands. [Image: Preston Huey, Science]