Contents
Vol 3, Issue 141
Contents
Research Articles
- Signaling from the Endoplasmic Reticulum Activates Brassinosteroid Signaling and Promotes Acclimation to Stress in Arabidopsis
BR signaling may integrate stress responses and growth processes to optimize growth under challenging environmental conditions.
- Molecular Mechanism of Calcium Channel Regulation in the Fight-or-Flight Response
Stimulation of cardiac Ca2+ channel activity by PKA in the fight-or-flight response requires an autoinhibitory complex with the distal C-terminal domain and a kinase anchoring protein.
- Coupling Mechanism of a GPCR and a Heterotrimeric G Protein During Chemoattractant Gradient Sensing in Dictyostelium
Imaging analyses and computer simulations suggest that a GPCR and its G protein associate only in the presence of ligand.
Perspectives
- β-Adrenergic Regulation of the L-Type Ca2+ Channel CaV1.2 by PKA Rekindles Excitement
Modulation of cardiac Ca2+ channels by protein kinase A in the fight-or-flight response involves their proteolytic processing and just the right amount of anchoring protein AKAP.
- Sphingolipids: The Oil on the TRAFire That Promotes Inflammation
Lipid second messengers are required for signaling through tumor necrosis factor and Toll-like receptors.
Editors' Choice
- Exit by Exosome
Two tetraspanins reduce β-catenin–dependent signaling by promoting the extracellular release of this signaling protein in exosomes.
- Shedding Light on FoxO Function
Vitamin D acts through its nuclear receptor to regulate FoxO function.
- NF-κB Needs PPARγ
Unliganded PPARγ is proinflammatory, whereas agonist-bound PPARγ is anti-inflammatory.
- Why Cell Signaling Is Noisy
Noise suppression in biochemical circuits comes at an extreme cost.
- Down with TRPV4
β-arrestin connects stimulation of a G protein–coupled receptor to down-regulation of an ion channel.
- Mr. Blebby
Altering the homeostasis of membrane-bound signaling molecules allows a bacterial pathogen to corrupt cell function.
- Innervation for Branching
Neuronal input is required for maintenance of epithelial progenitor cells in the mouse salivary gland.
- Discriminating Dendrites
Dendrites of neurons are sensitive to the sequence of synaptic activation and can implement cortical computation.
- α-Synuclein and Aging
A protein implicated in neurodegeneration promotes the assembly of membrane fusion complexes.
