Contents
Vol 3, Issue 142
Contents
Research Articles
- Apolipoprotein E Controls ATP-Binding Cassette Transporters in the Ischemic Brain
Apolipoprotein E regulates ATP-binding cassette drug transporters in the ischemic brain, thereby controlling the brain-to-blood drug distribution.
- Nonsynaptic Communication Through ATP Release from Volume-Activated Anion Channels in Axons
Axonal swelling allows neurons to communicate with glia by ATP released from volume-activated anion channels.
Perspective
- Mechanisms of Sperm-Egg Interactions: Between Sugars and Broken Bonds
New evidence reveals a more complex scenario for early events in mammalian fertilization.
Podcast
- Science Signaling Podcast: 5 October 2010
Inhibition of apolipoprotein E signaling is a potential clinical strategy for enhancing the delivery of neuroprotective drugs to the brain after ischemic stroke.
Editors' Choice
- SLAMming Bacteria
A receptor family previously characterized as adhesion and costimulatory molecules also acts as sensors for gram-negative bacteria.
- B Cell Receptor Togetherness
Activation of the B cell receptor appears to require release of the receptors from an autoinhibited, oligomeric state.
- No Intermediates Needed
The type 1 transforming growth factor–β receptor phosphorylates elongation factor eEF1A1 to inhibit translation.
- B-Raf Dependency
More than 80% inhibition of ERK activity is required to induce regression of melanoma tumors.
- Channel STIMulation
The sensor protein that monitors depletion of intracellular calcium regulates two classes of calcium entry channels.
- Smoke Gets in Your Lungs
Cigarette smoke promotes lung inflammation by hindering an enzyme that degrades an immune cell chemoattractant.
- Mechanical Responders Identified
Cation channel genes encode for a transducer molecule that converts mechanical stimuli into cell signaling.
- Closing the Vector Circle
The genome of a third mosquito species reveals distinctions related to vector capacities and habitat preferences.
