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Abstract
This is a conversation with Dirk Hermann about a Research Article published in the 5 October 2010 issue of Science Signaling. ElAli and Hermann report that apolipoprotein E (ApoE) regulates ATP-binding cassette (ABC) drug transporters in the ischemic brain, thereby controlling brain-to-blood drug distribution. Inhibition of ApoE signaling is a potential clinical strategy for enhancing the delivery of neuroprotective drugs to the brain after ischemic stroke.
