Contents
Vol 3, Issue 145
Contents
Research Articles
- PI3K Signaling Through the Dual GTPase–Activating Protein ARAP3 Is Essential for Developmental Angiogenesis
The guanosine triphosphatase–activating protein ARAP3 may be a target for antiangiogenic therapies.
- Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels
Coupling TRPC5 and TRPC6 calcium channels to different Rho GTPases allows calcium to both promote and inhibit cell migration.
- Regulation of 3-Phosphoinositide–Dependent Protein Kinase 1 Activity by Homodimerization in Live Cells
Spatial and temporal regulation of the homodimerization of PDK1 modulates its activity.
Perspective
- Delivering the Lateral Inhibition Punchline: It’s All About the Timing
New ways to understand lateral inhibition in patterning sensory bristles in the fruit fly are proposed.
Review
- Apoptosis, Stem Cells, and Tissue Regeneration
Cells undergoing stress- or injury-induced apoptosis can stimulate tissue regeneration by promoting stem or progenitor cell proliferation.
Podcast
- Science Signaling Podcast: 26 October 2010
Disrupting activity of the guanosine triphosphatase-activating protein ARAP3 is a potential strategy for anti-angiogenic therapy.
Editors' Choice
- Regional Variations
Intrinsic differences in mTORC2-dependent Akt activation underlie the region-specific effects of neurofibromatosis-1 on glial progenitor cell development.
- The Toll of Stress on Vessels
Activation of Toll-like receptor 2 by the products of lipid oxidation promotes angiogenesis independently of vascular endothelial growth factor.
- Stress, DNA Damage, and ATM
The protein kinase ATM is a sensor for reactive oxygen species.
- The Differences That Bind
Bacterial chemoreceptors can be classified on the basis of whether ligands bind directly or indirectly.
- M2 Out of the Envelope
A flurry of structural data provides sometimes conflicting insights into the M2 proton channel.
- PIAS1 Repression
A ligase regulates repression of the Foxp3 promoter to restrict differentiation of natural regulatory T cells.
- Three’s the Charm
Membrane fusion proteins cooperate to promote rapid secretory vesicle exocytosis from neuroendocrine cells.
Erratum
- A Correction to the Research Article Titled: "Sexually Dimorphic Actions of Glucocorticoids Provide a Link to Inflammatory Diseases with Gender Differences in Prevalence" by D. Duma, J. B. Collins, J. W. Chou, J. A. Cidlowski
The authors correct an error in panel B of Figure S8 of the Supplementary Materials.
