Research ArticleCancer Biology
DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination
- Zhanwen Du1,2,
- Jing Song3,*,
- Yong Wang1,2,*,
- Yiqing Zhao1,2,
- Kishore Guda2,4,5,
- Shuming Yang6,
- Hung-Ying Kao7,
- Yan Xu6,8,
- Joseph Willis2,9,
- Sanford D. Markowitz2,4,5,
- David Sedwick2,4,
- Robert M. Ewing1,3, and
- Zhenghe Wang1,2,10,†
- 1Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA.
- 2Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
- 3Case Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USA.
- 4Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
- 5Howard Hughes Medical Institute, Cleveland, OH 44106, USA.
- 6Cancer Pharmacology Core Facility, Case Western Reserve University, Cleveland, OH 44106, USA.
- 7Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.
- 8Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA.
- 9Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
- 10Genomic Medicine Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
- ↵†To whom correspondence should be addressed. E-mail: zhenghe.wang{at}case.edu
-
↵* These authors contributed equally to this work.
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Science Signaling 02 Nov 2010:
Vol. 3, Issue 146, pp. ra80
DOI: 10.1126/scisignal.2001462
Vol. 3, Issue 146, pp. ra80
DOI: 10.1126/scisignal.2001462
Zhanwen Du
1Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA.
2Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Jing Song
3Case Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USA.
Yong Wang
1Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA.
2Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Yiqing Zhao
1Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA.
2Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Kishore Guda
2Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
4Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
5Howard Hughes Medical Institute, Cleveland, OH 44106, USA.
Shuming Yang
6Cancer Pharmacology Core Facility, Case Western Reserve University, Cleveland, OH 44106, USA.
Hung-Ying Kao
7Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.
Yan Xu
6Cancer Pharmacology Core Facility, Case Western Reserve University, Cleveland, OH 44106, USA.
8Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA.
Joseph Willis
2Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
9Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Sanford D. Markowitz
2Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
4Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
5Howard Hughes Medical Institute, Cleveland, OH 44106, USA.
David Sedwick
2Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
4Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Robert M. Ewing
1Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA.
3Case Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USA.
Zhenghe Wang
1Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA.
2Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
10Genomic Medicine Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
