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vol. 3 no. 147 ra81
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History:
- Received March 22, 2010
- Accepted October 7, 2010
- .
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Copyright © 2010, American Association for the Advancement of Science
Research ArticleCancer
Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma
- Qi-Wen Fan1,2,3,4,
- Christine Cheng1,2,3,4,
- Chris Hackett1,2,3,4,
- Morri Feldman5,6,
- Benjamin T. Houseman5,6,
- Theodore Nicolaides1,2,3,4,
- Daphne Haas-Kogan3,4,
- C. David James3,
- Scott A. Oakes4,7,
- Jayanta Debnath4,7,
- Kevan M. Shokat5,6,8, and
- William A. Weiss1,2,3,4,*
- 1Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.
- 2Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.
- 3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.
- 4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.
- 5Program in Chemistry and Chemical Biology, University of California, San Francisco, CA 94158–9001, USA.
- 6Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–9001, USA.
- 7Department of Pathology, University of California, San Francisco, CA 94158–9001, USA.
- 8Howard Hughes Medical Institute, University of California, San Francisco, CA 94158–9001, USA.
- ↵*To whom correspondence should be addressed. E-mail: weiss{at}cgl.ucsf.edu
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Science Signaling 09 Nov 2010:
Vol. 3, Issue 147, pp. ra81
DOI: 10.1126/scisignal.2001017
Vol. 3, Issue 147, pp. ra81
DOI: 10.1126/scisignal.2001017
Qi-Wen Fan
1Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.
2Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.
3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.
4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.
Christine Cheng
1Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.
2Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.
3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.
4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.
Chris Hackett
1Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.
2Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.
3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.
4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.
Morri Feldman
5Program in Chemistry and Chemical Biology, University of California, San Francisco, CA 94158–9001, USA.
6Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–9001, USA.
Benjamin T. Houseman
5Program in Chemistry and Chemical Biology, University of California, San Francisco, CA 94158–9001, USA.
6Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–9001, USA.
Theodore Nicolaides
1Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.
2Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.
3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.
4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.
Daphne Haas-Kogan
3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.
4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.
C. David James
3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.
Scott A. Oakes
4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.
7Department of Pathology, University of California, San Francisco, CA 94158–9001, USA.
Jayanta Debnath
4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.
7Department of Pathology, University of California, San Francisco, CA 94158–9001, USA.
Kevan M. Shokat
5Program in Chemistry and Chemical Biology, University of California, San Francisco, CA 94158–9001, USA.
6Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–9001, USA.
8Howard Hughes Medical Institute, University of California, San Francisco, CA 94158–9001, USA.
William A. Weiss
1Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.
2Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.
3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.
4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.
