Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

Qi-Wen Fan; Christine Cheng; Chris Hackett; Morri Feldman; Benjamin T. Houseman; Theodore Nicolaides; Daphne Haas-Kogan; C. David James; Scott A. Oakes; Jayanta Debnath; Kevan M. Shokat; William A. Weiss

doi:10.1126/scisignal.2001017

Research ArticleCancer

Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

Qi-Wen Fan¹,²,³,⁴,
Christine Cheng¹,²,³,⁴,
Chris Hackett¹,²,³,⁴,
Morri Feldman⁵,⁶,
Benjamin T. Houseman⁵,⁶,
Theodore Nicolaides¹,²,³,⁴,
Daphne Haas-Kogan³,⁴,
C. David James³,
Scott A. Oakes⁴,⁷,
Jayanta Debnath⁴,⁷,
Kevan M. Shokat⁵,⁶,⁸, and
William A. Weiss¹,²,³,⁴,*

¹Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.
²Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.
³Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.
⁴Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.
⁵Program in Chemistry and Chemical Biology, University of California, San Francisco, CA 94158–9001, USA.
⁶Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–9001, USA.
⁷Department of Pathology, University of California, San Francisco, CA 94158–9001, USA.
⁸Howard Hughes Medical Institute, University of California, San Francisco, CA 94158–9001, USA.

↵*To whom correspondence should be addressed. E-mail: weiss{at}cgl.ucsf.edu

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Science Signaling 09 Nov 2010:
Vol. 3, Issue 147, pp. ra81
DOI: 10.1126/scisignal.2001017

Qi-Wen Fan

1Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.

2Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.

3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.

4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.

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Christine Cheng

1Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.

2Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.

3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.

4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.

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Chris Hackett

1Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.

2Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.

3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.

4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.

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Morri Feldman

5Program in Chemistry and Chemical Biology, University of California, San Francisco, CA 94158–9001, USA.

6Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–9001, USA.

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Benjamin T. Houseman

5Program in Chemistry and Chemical Biology, University of California, San Francisco, CA 94158–9001, USA.

6Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–9001, USA.

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Theodore Nicolaides

1Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.

2Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.

3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.

4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.

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Daphne Haas-Kogan

3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.

4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.

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C. David James

3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.

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Scott A. Oakes

4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.

7Department of Pathology, University of California, San Francisco, CA 94158–9001, USA.

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Jayanta Debnath

4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.

7Department of Pathology, University of California, San Francisco, CA 94158–9001, USA.

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Kevan M. Shokat

5Program in Chemistry and Chemical Biology, University of California, San Francisco, CA 94158–9001, USA.

6Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–9001, USA.

8Howard Hughes Medical Institute, University of California, San Francisco, CA 94158–9001, USA.

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William A. Weiss

1Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.

2Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.

3Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.

4Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.

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For correspondence: weiss@cgl.ucsf.edu

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