Contents
Vol 3, Issue 148
Contents
Research Articles
- Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism
A cytoplasmic domain in STIM1 acts as a decoy to block the ability of STIM1 to bind to and activate Orai1.
- Solution of the Structure of the TNF-TNFR2 Complex
Structural differences in the binding of tumor necrosis factor to its two receptors may aid in the development of receptor-specific therapeutics.
Perspectives
- Calcium Signaling by STIM and Orai: Intimate Coupling Details Revealed
Intramolecular interactions within STIM1 control activation of Orai1 channels.
- Frizzled Signaling: Gαo and Rab5 at the Crossroads of the Canonical and PCP Pathways?
Rab5, a key effector of endocytosis, binds to Frizzled proteins, modulating their trafficking and signaling.
Editors' Choice
- Why Pigeon Doo May Be Bad for You
A “futile cycle” of transcription allows a pathogenic organism to rapidly respond to conditions favoring sexual reproduction.
- Flow into a New Cell Size
Fluid flow activates the LKB1-AMPK pathway in cilia to inhibit mTORC1-mediated increases in cell size.
- Reducing Inhibition Can Enhance Recovery
Targeting tonic GABA-mediated inhibition in the appropriate time frame may provide a therapeutic strategy to enhance recovery from stroke.
- Interfering with Tolerance
Interferon-γ promotes the activation of macrophages by facilitating chromatin remodeling of proinflammatory genes.
- Fungal Invasion or Pollination?
In Arabidopsis, development and disease use the same pollen-tube or hyphal tip-growing strategies.
- Plumbing in the Brain
A factor is identified that determines the amount of vasculature in the brain and, in doing so, affects brain function.
- Reciprocal Regulation
A crystal structure shows how the two components of a central signaling complex regulate each other.
