16 November 2010
Vol 3, Issue 148

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article that presents the crystal structure of tumor necrosis factor (TNF) in complex with one of its receptors, TNFR2. Comparison of this structure with the known structure of the other TNF receptor, TNFR1, may aid in the development of receptor-specific therapies for diseases such as rheumatoid arthritis and Crohn's disease. Current therapies against TNF have many side effects and do not differentiate between receptors. The image shows TNF (green) in complex with TNFR2 (blue) and is based on PDB structure 3alq. [Image: Chris Bickel, AAAS]