Contents
Vol 3, Issue 150
Contents
Research Article
- The Extracellular Domain of Fibroblast Growth Factor Receptor 3 Inhibits Ligand-Independent Dimerization
The extracellular domain of a receptor tyrosine kinase has opposing effects on dimerization depending on whether ligand is present.
Perspective
- Compartment-Specific Control of Signaling from a DNA-Sensing Immune Receptor
The endosomal compartment in which TLR9 is activated determines which cytokines are produced.
Editors' Choice
- Zap70 as an Adaptor
The tyrosine kinase Zap70 has kinase-independent functions during T cell activation.
- Dephosphorylation to Die For
Induction of apoptosis requires dephosphorylation of a regulatory protein in the mitochondrial outer membrane.
- Lynx Vision
A gene identified in the mouse may show the way to improved treatments for amblyopia, a condition of indistinct vision.
- Promoting Apoptosis
The promyelocytic leukemia protein likely influences apoptosis by influencing a calcium channel in the endoplasmic reticulum.
- Cellular Devices
Cells engineered to detect a cancer-associated marker produce a protein that sensitizes them to an anticancer drug.
