Contents
Vol 3, Issue 151
Contents
Editorial Guide
- Focus Issue: Metabolic Signals
Complementing the Science Special Issue, this issue highlights signaling pathways with roles in metabolism.
Research Articles
- A Kinase-Independent Role for Unoccupied Insulin and IGF-1 Receptors in the Control of Apoptosis
Cells lacking both insulin and IGF-1 receptors are resistant to apoptosis.
- Regulation of the 26S Proteasome Complex During Oxidative Stress
Oxidative stress triggers release of the core catalytic subunit of the yeast 26S proteasome, enabling degradation of toxic oxidized proteins.
Research Resource
- ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage
Quantitative phosphoproteomics suggests that kinases other than ATM participate in the initial phase of the cellular response to DNA double-strand breaks.
Perspectives
- Lipid Signaling and Homeostasis: PA- Is Better than PA-H, But What About Those PIPs?
Phosphatidic acid links changes in pH triggered by glucose metabolism to phospholipid biogenesis in yeast.
- Dependence Receptors: The Trophic Theory Revisited
Some receptor tyrosine kinases can activate apoptotic pathways in the absence of ligand.
Protocol
- Planar Patch Clamp Approach to Characterize Ionic Currents from Intact Lysosomes
Glass chips and gentle isolation are the keys to recording channels from intracellular organelles.
Podcast
- Science Signaling Podcast: 7 December 2010
Oxidative stress induces separation of the catalytic and regulatory portions of the yeast 26S proteasome, enabling the catalytic core to degrade toxic oxidized proteins.
Editors' Choice
- Inflammatory Decline
The pro-inflammatory cytokine tumor necrosis factor triggers cognitive decline after surgery.
- mTORC2 Akt-ing at the Ribosome
mTORC2-mediated phosphorylation of Akt occurs during translation.
- ERKed About Lamin A
ERK can promote cell proliferation through a mechanism independent of its catalytic activity.
- Pain in the Brain
Nerve injury increases the activity of an enzyme in the brain and contributes to chronic pain–related cortical sensitization.
- Live or Die with ErbB4
Alternative splice variants of the receptor tyrosine kinase ErbB4 trigger proliferation or death.
- Deadly Trio
Proapoptotic proteins act directly on mitochondrial “gatekeeper” proteins to initiate apoptotic events during mouse development.
- The Yin and Yang of Plant Caspases
An ancient link between cell death control and innate immune receptor function has been discovered in plants.
- DNA Damage Pathways Revealed
A network comparison of genetic interactions mapped at two conditions reveals genetic responses to DNA damage in yeast.
- Just Beet It
A homolog of a flowering time gene has evolved a flowering repression function, affecting the seasonal cold response in beet.
