07 December 2010
Vol 3, Issue 151

About The Cover

Cover image expansion

Online Cover This week, Science Signaling publishes a Focus Issue that complements the Science Special Issue on Metabolism. Highlights include an unexpected role in triggering apoptosis for the insulin receptor and the related IGF-1 receptor (known for their roles in metabolism and growth), a role for lipids as cellular sensors of glucose metabolism, and a mechanism whereby cells can survive oxidative stress by shifting the activity of the cell's protein degradation complex. The image shows an artist's depiction of the two processes of metabolism: building (anabolic) and disassembling (catabolic). [Image: Chris Bickel, AAAS]