Contents
Vol 3, Issue 152
Contents
Research Article
- A Conceptual Molecular Network for Chemotactic Behaviors Characterized by Feedback of Molecules Cycling Between the Membrane and the Cytosol
Simulations and observations of migrating cells suggest a model for feedback loops that regulate chemotaxis.
Perspectives
- Aspasing Out Metacaspases and Caspases: Proteases of Many Trades
The substrates of the metacaspase type of proteases are beginning to be identified.
- Myc-Nick: The Force Behind c-Myc
A cytoplasmic form of c-Myc promotes microtubule stability and cell differentiation.
Review
- INTERSECTINg Pathways in Cell Biology
The intersectin family of scaffolding proteins link signaling and endocytic pathways.
Editors' Choice
- Neuronal ER Stress
Inositol trisphosphate receptors (IP3Rs) are central to the neuronal response to endoplasmic reticulum stress.
- IP7 Akts as an Inhibitor
Insulin signaling stimulates the generation of the inositol pyrophosphate IP7, which inhibits the activation of Akt, thus attenuating insulin signaling.
- Connecting Signaling and Metabolism in Cancer
A signaling pathway often activated in cancer cells influences aerobic glycolysis and growth factor receptor expression.
- Coordinating Metabolism with Oxygen Supply
Hypoxic conditions activate the kinase ATM to inhibit a complex central to metabolism, mTORC1.
- Muscle Building
An alternative signaling mechanism for nucleating unbranched actin filaments is required for skeletal muscle maturation.
- Getting HIV Under Control
MHC class I alleles are the major genetic determinants associated with people able to control HIV infection without therapy.
