21 December 2010
Vol 3, Issue 153
  • Contents

    • Research Articles

    • Research Resource

    • Perspectives

    • Podcast

      • Science Signaling Podcast: 21 December 2010

        Targeted removal of individual enzymes elicits changes throughout the entire network of kinases and phosphatases in yeast.

    • Editors' Choice

      • Dermal Light Detectors

        Fly larvae detect high-intensity light all over their bodies, not just with their primitive eyes.

      • When Breaking Up Is Not Depressing

        Disruption of the dopamine D1-D2 receptor complex may provide a therapeutic strategy against depression.

      • Mimicry in Akt-ion

        A viral kinase mimics the activity of Akt despite their lack of sequence similarity.

      • Migrating Cells Need TORC

        Cells lacking mTORC2 activity exhibit defects in polarization and chemotaxis.

      • Beyond the Greatwall

        The protein kinase Greatwall controls cell division by phosphorylating and activating inhibitors of protein phosphatase 2A.

      • Aiding the Invaders?

        Mesenchymal stem cells contribute to the ability of Mycobacterium tuberculosis to establish a persistent infection.

      • Metabolism Without Modification

        A drug inhibiting the activation of ghrelin, a peptide that promotes weight gain, has beneficial metabolic effects in mice.

      • GlcNAc in Place of Glucose

        Addition of N-acetylglucosamine to the medium can substitute for glucose in maintaining cell growth, but not proliferation.

      • Size Matters

        The central nervous system and the hormone ecdysone govern wing-size scaling in the tobacco hornworm.

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes a signaling pathway that transmits mechanical force into increased bone cell proliferation, which may lead to the development of drugs targeting this pathway that could mimic the bone-building effects of mechanical stimulation. The image shows an artist's representation of an elbow connected to a force meter and a mechanical damper. [Image Credit: Chris Bickel, AAAS, and Thinkstock]