Contents
Vol 3, Issue 153
Contents
Research Articles
- The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier
Analysis of ERK pathway circuitry suggests appropriate targets for inhibition, providing a guide for drug development.
- Cyclic GMP and Protein Kinase G Control a Src-Containing Mechanosome in Osteoblasts
Drugs that activate protein kinase G could mimic the bone-building effects of mechanical stimulation.
Research Resource
- Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast
A system-wide analysis of protein phosphorylation in yeast reveals robustness in the network of kinases and phosphatases.
Perspectives
- T Cell Receptor Signaling Kinetics Takes the Stage
The kinetics of TCR signaling influence the quality of the T cell response.
- Mechanosomes Carry a Loaded Message
Mechanical cues at the bone cell membrane can alter gene transcription through various signaling pathways.
Podcast
- Science Signaling Podcast: 21 December 2010
Targeted removal of individual enzymes elicits changes throughout the entire network of kinases and phosphatases in yeast.
Editors' Choice
- Dermal Light Detectors
Fly larvae detect high-intensity light all over their bodies, not just with their primitive eyes.
- When Breaking Up Is Not Depressing
Disruption of the dopamine D1-D2 receptor complex may provide a therapeutic strategy against depression.
- Mimicry in Akt-ion
A viral kinase mimics the activity of Akt despite their lack of sequence similarity.
- Migrating Cells Need TORC
Cells lacking mTORC2 activity exhibit defects in polarization and chemotaxis.
- Beyond the Greatwall
The protein kinase Greatwall controls cell division by phosphorylating and activating inhibitors of protein phosphatase 2A.
- Aiding the Invaders?
Mesenchymal stem cells contribute to the ability of Mycobacterium tuberculosis to establish a persistent infection.
- Metabolism Without Modification
A drug inhibiting the activation of ghrelin, a peptide that promotes weight gain, has beneficial metabolic effects in mice.
- GlcNAc in Place of Glucose
Addition of N-acetylglucosamine to the medium can substitute for glucose in maintaining cell growth, but not proliferation.
- Size Matters
The central nervous system and the hormone ecdysone govern wing-size scaling in the tobacco hornworm.
