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vol. 3 no. 153 rs4
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History:
- Received May 14, 2010
- Accepted December 3, 2010
- .
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Copyright © 2010, American Association for the Advancement of Science
Research ResourceSystems Biology
Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast
- Bernd Bodenmiller1,2,*,†,
- Stefanie Wanka2,3,*,
- Claudine Kraft4,
- Jörg Urban5,
- David Campbell6,
- Patrick G. Pedrioli4,‡,
- Bertran Gerrits7,§,
- Paola Picotti1,
- Henry Lam8,
- Olga Vitek9,
- Mi-Youn Brusniak6,
- Bernd Roschitzki7,
- Chao Zhang10,
- Kevan M. Shokat10,
- Ralph Schlapbach7,
- Alejandro Colman-Lerner11,
- Garry P. Nolan12,
- Alexey I. Nesvizhskii13,
- Matthias Peter4,
- Robbie Loewith5,
- Christian von Mering3, and
- Ruedi Aebersold1,6,14,||
- 1Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.
- 2Zurich PhD Program in Molecular Life Sciences, 8057 Zurich, Switzerland.
- 3Institute of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, 8057 Zurich, Switzerland.
- 4Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland.
- 5Department of Molecular Biology, University of Geneva, Geneva 1211, Switzerland.
- 6Institute for Systems Biology, Seattle, WA 98103, USA.
- 7Functional Genomics Center Zurich, University Zurich and ETH Zurich, 8057 Zurich, Switzerland.
- 8Department of Chemical and Biomolecular Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.
- 9Departments of Statistics and Computer Science, Purdue University, West Lafayette, IN 47107, USA.
- 10Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–2280, USA.
- 11Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, C1428EHA Buenos Aires, Argentina.
- 12Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
- 13Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
- 14Faculty of Science, University of Zurich, 8057 Zurich, Switzerland.
- ↵||To whom correspondence should be addressed. E-mail: aebersold{at}imsb.biol.ethz.ch
-
↵* These authors contributed equally to this work.
-
↵† Present address: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
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↵‡ Present address: Scottish Institute for Cell Signalling, Sir James Black Centre, University of Dundee, Dundee, Scotland DD1 5EH, UK.
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↵§ Present address: Novartis Institute for Biomedical Research, Novartis International AG, CH-4002 Basel, Switzerland.
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Science Signaling 21 Dec 2010:
Vol. 3, Issue 153, pp. rs4
DOI: 10.1126/scisignal.2001182
Vol. 3, Issue 153, pp. rs4
DOI: 10.1126/scisignal.2001182
Bernd Bodenmiller
1Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.
2Zurich PhD Program in Molecular Life Sciences, 8057 Zurich, Switzerland.
Stefanie Wanka
2Zurich PhD Program in Molecular Life Sciences, 8057 Zurich, Switzerland.
3Institute of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, 8057 Zurich, Switzerland.
Claudine Kraft
4Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland.
Jörg Urban
5Department of Molecular Biology, University of Geneva, Geneva 1211, Switzerland.
David Campbell
6Institute for Systems Biology, Seattle, WA 98103, USA.
Patrick G. Pedrioli
4Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland.
Bertran Gerrits
7Functional Genomics Center Zurich, University Zurich and ETH Zurich, 8057 Zurich, Switzerland.
Paola Picotti
1Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.
Henry Lam
8Department of Chemical and Biomolecular Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.
Olga Vitek
9Departments of Statistics and Computer Science, Purdue University, West Lafayette, IN 47107, USA.
Mi-Youn Brusniak
6Institute for Systems Biology, Seattle, WA 98103, USA.
Bernd Roschitzki
7Functional Genomics Center Zurich, University Zurich and ETH Zurich, 8057 Zurich, Switzerland.
Chao Zhang
10Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–2280, USA.
Kevan M. Shokat
10Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–2280, USA.
Ralph Schlapbach
7Functional Genomics Center Zurich, University Zurich and ETH Zurich, 8057 Zurich, Switzerland.
Alejandro Colman-Lerner
11Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, C1428EHA Buenos Aires, Argentina.
Garry P. Nolan
12Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alexey I. Nesvizhskii
13Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Matthias Peter
4Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland.
Robbie Loewith
5Department of Molecular Biology, University of Geneva, Geneva 1211, Switzerland.
Christian von Mering
3Institute of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, 8057 Zurich, Switzerland.
Ruedi Aebersold
1Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland.
6Institute for Systems Biology, Seattle, WA 98103, USA.
14Faculty of Science, University of Zurich, 8057 Zurich, Switzerland.
