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Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

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Science Translational Medicine  03 Aug 2011:
Vol. 3, Issue 94, pp. 94ra70
DOI: 10.1126/scitranslmed.3002394

Article Information

vol. 3 no. 94 94ra70

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 14, 2011
  • Accepted for publication June 23, 2011

Author Information

  1. Denise A. Chan1,2,*,
  2. Patrick D. Sutphin3,*,
  3. Phuong Nguyen1,
  4. Sandra Turcotte4,
  5. Edwin W. Lai1,
  6. Alice Banh1,
  7. Gloria E. Reynolds2,
  8. Jen-Tsan Chi5,
  9. Jason Wu6,
  10. David E. Solow-Cordero6,
  11. Muriel Bonnet7,
  12. Jack U. Flanagan7,
  13. Donna M. Bouley8,
  14. Edward E. Graves1,
  15. William A. Denny7,
  16. Michael P. Hay7 and
  17. Amato J. Giaccia1,
  1. 1Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  2. 2Department of Radiation Oncology, University of California, San Francisco, CA 94143, USA.
  3. 3Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
  4. 4Université de Moncton, Moncton, New Brunswick E1A 3E9, Canada.
  5. 5Institute for Genome Sciences and Policy, Department of Molecular Genetics and Microbiology, Duke Medical Center, Durham, NC 27708, USA.
  6. 6High-Throughput Bioscience Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
  7. 7Auckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
  8. 8Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  1. To whom correspondence should be addressed. E-mail: giaccia{at}stanford.edu

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