Contents
Vol 4, Issue 154
Contents
Editorial Guide
- 2010: Signaling Breakthroughs of the Year
The editors highlight the year's cell signaling breakthroughs.
Research Resource
- A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint
The DNA damage response in Drosophila requires the replication preinitiation complex and the MUS312 nuclease complex.
Journal Club
- Protein S-Nitrosylation in Plants: Photorespiratory Metabolism and NO Signaling
S-nitrosylation of mitochondrial proteins induces cell death in the plant pathogen defense response.
Podcast
- Science Signaling Podcast: 4 January 2011
Chief Scientific Editor Michael Yaffe reviews the past year in Science Signaling.
Editors' Choice
- Confined to Quarters?
Canonical Wnt signaling involves sequestration of glycogen synthase kinase 3.
- Memory-Stealing Caspase
Caspase-3 plays an apoptosis-independent role in the early pathogenesis of Alzheimer’s disease.
- Understanding Atrophy
The scaffold and ubiquitin ligase TRAF6 plays a key role in muscle wasting.
- Beyond Cell Cycle Control
A phosphatase normally associated with cell cycle control is required for ciliogenesis in zebrafish.
- Exiting the Birthplace
A ubiquitination cascade regulates formation of cell adhesions that immature neurons require in the developing mouse brain.
- PP2A, the Key to Life and Death
By recruiting active protein phosphatase 2A (PP2A) complexes or a PP2A inhibitor, the UNC5H2 dependence receptor triggers death or survival, respectively.
- A Safety Catch on Immune Response
A double safety-catch mechanism controls amplification of the complement cascade during immune responses.
- Immune Protection from Metabolic Syndrome?
An immune profile that is biased toward the TH2 anti-inflammatory side regulates hepatic metabolism and limits adipose inflammation.
- Exploiting Variation
A molecular chaperone both buffers and potentiates the adaptive nature of genetic variation in yeast.
