Contents
Vol 4, Issue 157
Contents
Research Articles
- Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch
Mechanical stretch activates Rho-kinase in adipocytes, promoting obesity and obesity-related complications.
- Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling
Loss of the kinase and tumor suppressor Stk11 (Lkb1) has opposite effects on Hh and Wnt signaling.
- V2 Receptor–Mediated Autocrine Role of Somatodendritic Release of AVP in Rat Vasopressin Neurons Under Hypo-Osmotic Conditions
The antidiuretic hormone arginine vasopressin (AVP) is also an autocrine signal, allowing the hypothalamic neurons that produce it to maintain their volume during hypotonic stress.
Perspective
- Control of DNMT1 Abundance in Epigenetic Inheritance by Acetylation, Ubiquitylation, and the Histone Code
The protein stability of a DNA methyltransferase is determined by acetylation and ubiquitylation.
Journal Club
- The Role of L(u)ck in T Cell Triggering
The Src family kinase Lck is activated prior to T cell receptor engagement and poised for action upon antigen binding.
Meeting Report
- Dependence Receptors: From Basic Research to Drug Development
Discussion at a meeting in France focused on new insights into the biology of dependence receptors.
Podcast
- Science Signaling Podcast: 25 January 2011
Researchers discuss recent findings on how mechanical stretch regulates signaling pathways in adipocytes and in hypothalamic neurons.
Editors' Choice
- Regulating Ras Trafficking with FKPB12
By promoting Ras depalmitoylation, the prolyl isomerase FKBP12 regulates Ras trafficking and activity.
- Lost Without a Raft
Cholesterol depletion enhances the proteolytic cleavage and release of the adhesion molecule CD44 and can inhibit glioma cell migration.
- A Roundabout Way to Vascularization
Robo4 acts as an in trans ligand for UNC5B in vascular endothelium to restrict angiogenesis.
- Rallying the Troops
A protein complex involved in the targeting of vesicles to the plasma membrane also acts as a platform for components of the autophagy machinery.
- Immune Evasion Tactic
A viral homolog of a host microbial sensor inhibits viral detection by the host and subsequent antiviral immunity.
- Clostridium to the Rescue
Bacteria of the genus Clostridium promote the induction of suppressor T cells in the colons of mice.
