Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch

Yoshikazu Hara; Shu Wakino; Yoshiyuki Tanabe; Maki Saito; Hirobumi Tokuyama; Naoki Washida; Satoru Tatematsu; Kyoko Yoshioka; Koichiro Homma; Kazuhiro Hasegawa; Hitoshi Minakuchi; Keiko Fujimura; Koji Hosoya; Koichi Hayashi; Koichi Nakayama; Hiroshi Itoh

doi:10.1126/scisignal.2001227

Research ArticleMetabolism

Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch

Yoshikazu Hara¹,
Shu Wakino¹,*,
Yoshiyuki Tanabe²,
Maki Saito²,
Hirobumi Tokuyama¹,
Naoki Washida¹,
Satoru Tatematsu¹,
Kyoko Yoshioka¹,
Koichiro Homma¹,
Kazuhiro Hasegawa¹,
Hitoshi Minakuchi¹,
Keiko Fujimura¹,
Koji Hosoya¹,
Koichi Hayashi¹,
Koichi Nakayama², and
Hiroshi Itoh¹

¹Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
²Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Iwate 028-3694, Japan.

↵*To whom correspondence should be addressed. E-mail: swakino{at}sc.itc.keio.ac.jp

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Science Signaling 25 Jan 2011:
Vol. 4, Issue 157, pp. ra3
DOI: 10.1126/scisignal.2001227

Yoshikazu Hara

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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Shu Wakino

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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For correspondence: swakino@sc.itc.keio.ac.jp

Yoshiyuki Tanabe

Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Iwate 028-3694, Japan.

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Maki Saito

Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Iwate 028-3694, Japan.

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Hirobumi Tokuyama

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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Naoki Washida

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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Satoru Tatematsu

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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Kyoko Yoshioka

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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Koichiro Homma

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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Kazuhiro Hasegawa

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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Hitoshi Minakuchi

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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Keiko Fujimura

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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Koji Hosoya

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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Koichi Hayashi

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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Koichi Nakayama

Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University, Iwate 028-3694, Japan.

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Hiroshi Itoh

Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch

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