Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling

Leni S. Jacob; Xiaofeng Wu; Michael E. Dodge; Chih-Wei Fan; Ozlem Kulak; Baozhi Chen; Wei Tang; Baolin Wang; James F. Amatruda; Lawrence Lum

doi:10.1126/scisignal.2001225

Research ArticleCell Biology

Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling

Leni S. Jacob¹,
Xiaofeng Wu¹,
Michael E. Dodge¹,
Chih-Wei Fan¹,
Ozlem Kulak¹,
Baozhi Chen¹,
Wei Tang¹,*,
Baolin Wang²,³,
James F. Amatruda⁴,⁵, and
Lawrence Lum¹,†

¹Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
²Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA.
³Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
⁴Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
⁵Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

↵†To whom correspondence should be addressed. E-mail: lawrence.lum{at}UTSouthwestern.edu

↵* Present address: BioDuro Co. Ltd., No. 29 Building, Life Science Park Road, Changping District, 102206 Beijing, People’s Republic of China.

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Science Signaling 25 Jan 2011:
Vol. 4, Issue 157, pp. ra4
DOI: 10.1126/scisignal.2001225

Leni S. Jacob

1Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Xiaofeng Wu

2Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA.

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Michael E. Dodge

1Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Chih-Wei Fan

1Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Ozlem Kulak

1Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Baozhi Chen

1Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Wei Tang

1Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Baolin Wang

2Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA.

3Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

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James F. Amatruda

4Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

5Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Lawrence Lum

1Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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For correspondence: lawrence.lum@UTSouthwestern.edu

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