Research ArticleImmunology

Mitochondrial Membrane Potential Is Required for MAVS-Mediated Antiviral Signaling

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Science Signaling  01 Feb 2011:
Vol. 4, Issue 158, pp. ra7
DOI: 10.1126/scisignal.2001147

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Antiviral Mitochondrial Action

Mitochondria are the energy generators of the cell, but they also act as platforms upon which complexes of proteins respond to RNA-containing viruses within the cytosol. Through genetic and pharmacological means, Koshiba et al. present evidence that suggests that the contribution of mitochondria to these antiviral responses is not as passive as originally thought. Indeed, their data suggest that successful resistance to viral infections depends on maintenance of the internal physiological functions of mitochondria coupled with the functions of the external protein complexes.