Contents
Vol 4, Issue 159
Contents
Research Article
- The Crystal Structure of a Self-Activating G Protein α Subunit Reveals Its Distinct Mechanism of Signal Initiation
The Arabidopsis G protein α subunit exhibits properties necessary and sufficient for receptor-independent activation.
Perspectives
- Gαq and Phospholipase C-β: Turn On, Turn Off, and Do It Fast
A crystal structure illuminates reciprocal regulation between a G protein and its effector.
- How Cells Use Pseudopods for Persistent Movement and Navigation
A model of pseudopod formation, splitting, and persistence describes how cells migrate.
Editors' Choice
- Repair and Protect
By stimulating metabolic flux through the pentose phosphate pathway, ATM promotes the production of nucleotides for DNA repair and limits production of reactive oxygen species.
- Making It Short and Sweet
O-linked β-N-acetylglucosamine transferase cleaves HCF-1, as well as glycosylating it, in a process necessary for its functional activation.
- Oncogenic MyD88
A gain-of-function mutation in MyD88 promotes survival of a B cell lymphoma through activation of NF-κB and JAK-STAT signaling pathways.
- Limiting Inflammatory Signaling with EPO
Erythropoietin inhibits NF-κB activation in macrophages and thus limits proinflammatory signaling.
- USE During Stress
Stress-induced activation of p38 promotes more efficient processing of USE-containing mRNAs, including that encoding thrombin.
- Wearing the Same Cap
Some viruses evade detection by encoding enzymes that modify the structures of their coding RNAs to match those of their hosts.
- Time for a Pause
A peptide-mediated translational pause facilitates the unconventional splicing of a messenger RNA on the endoplasmic reticulum.
- Not So Different After All
Dissociation of a plant receptor kinase inhibitor from its substrate is mediated by tyrosine phosphorylation.
- Variation in Transit
The waveform of an action potential can be physiologically modified while it travels along the axon.
- A Tale of Two Stomata
The transition from passive to active metabolic control of stomata and plant water balance occurred about 360 million years ago.
