Contents
Vol 4, Issue 161
Contents
Research Articles
- ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3β–Mediated Phosphorylation of Rictor
Cellular stress attenuates growth factor signaling through a phosphorylation event that blocks substrate access to the kinase complex mTORC2.
- The Specificity of Innate Immune Responses Is Enforced by Repression of Interferon Response Elements by NF-κB p50
Binding of NF-κB p50 homodimers to an interferon response element restricts interferon signaling and antiviral responses to only the appropriate stimuli.
Meeting Report
- Receptors, Signaling Networks, and Disease
This meeting in Madrid focused on signaling by immune cells and regulation of and signaling by G protein–coupled receptors.
Podcast
- Science Signaling Podcast: 22 February 2011
A transcriptional repressor acts as a gatekeeper to restrict the innate immune response to specific stimuli.
Editors' Choice
- Cofactor for Amino Acid Stimulation
Inositol polyphosphate multikinase stabilizes the mTORC1 complex and enhances amino acid–induced signaling.
- Neogenin, a “Neo” Receptor for BMP
Bone morphogenetic proteins (BMPs) bind the receptor neogenin to trigger pathways that inhibit BMP signaling through the transcriptional regulators Smads.
- A Helping Hand for Implantation
Progesterone opposes estrogen-induced uterine epithelial proliferation through the transcription factor Hand2.
- AKTing as Individuals
Heterogeneity in AKT activity in cell populations depends on differences in phosphoinositide 3-kinase abundance.
- Two Ways to Plant Symbiosis
Parasponia uses a mycorrhizal signaling receptor essential for arbuscle formation to control rhizobium nodule symbiosis.
- Mastering Memory Maintenance
Tagging of cortical networks at the time of encoding is crucial for long-lasting associative memories.
