01 March 2011
Vol 4, Issue 162
  • Contents

    • Research Article

    • Perspective

    • Editors' Choice

      • Terms of Disengagement

        To prevent destruction of self, inhibitory receptors block clustering of activating receptors and cause natural killer cells to disengage.

      • Tregs Promote Metastasis

        Receptor activator of nuclear factor κB ligand (RANKL) produced by regulatory T cells triggers the metastasis of breast cancer cells.

      • Touch Off a Fight

        A contact pheromone produced by females induces aggression in male squid.

      • Sphingolipids and Retinal Degeneration

        Too much dihydrosphingosine 1-phosphate enhances degradation of photoreceptor membrane proteins and leads to retinal degeneration in flies.

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article describing how adenosine triphosphate (ATP) signaling through purinergic receptors reduces the immunosuppressive effects of regulatory T cells (Tregs). In addition, ATP induced the conversion of Tregs to proinflammatory cells. The image shows a section of mouse colon that exhibits infiltrating inflammatory cells because some of the Tregs in the tissue have been rendered ineffective by ATP. [Image: Michele Proietti, Institute for Research in Biomedicine, Bellinzona, Switzerland]