Contents
Vol 4, Issue 163
Contents
Research Articles
- Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors
Cancers in which K-Ras activation drives tumor growth could be targeted by treatments blocking K-Ras ubiquitination.
- Vav1-Mediated Scaffolding Interactions Stabilize SLP-76 Microclusters and Contribute to Antigen-Dependent T Cell Responses
Scaffolding functions of Vav1 contribute to SLP-76 clustering and signaling downstream of the T cell receptor.
Perspective
- Ubiquitin on Ras: Warden or Partner in Crime?
Ubiquitination of different Ras isoforms has distinct effects on abundance, activity, and access to effectors.
Podcast
- Science Signaling Podcast: 8 March 2011
Mathematical analysis reveals how a graded signal can induce a homogeneous response across a field of cells.
Editors' Choice
- Bones Promote Male Fertility
Osteocalcin, a peptide hormone produced in bone cells, controls production of the steroid hormone testosterone in the testes.
- Death by Lysosome
A Stat3-regulated pathway leads to lysosomal membrane permeabilization and reduced inhibition of cathepsin activity to promote mammary gland involution.
- Eliminating Unnecessary Repair Machinery?
Acetylation coordinates the DNA double-strand break processing with autophagy.
- FATtening Up Against Neurodegeneration
A neurodegenerative disorder could be caused by decreased signaling through the Hippo pathway.
- Dual Mode of Oncogenesis
Oncogenic Ras mutants stimulate the first kinase in the MAPK pathway (Raf) and prevent SUMOylation-mediated inhibition of the second kinase, MEK.
- Sizing Signals
Mitosis starts when morphogen signaling levels have increased by half since the beginning of the cell cycle.
- Break It Down, Sweep It Out
Natural-product effectors of disease resistance in Arabidopsis reveal complementary disabling mechanisms in the pathogen.
- Netting Pancreatic Cancer Genes
A rare but deadly form of human pancreatic cancer harbors mutations in chromatin remodeling genes.
- Improving Old Memories
In rats, overexpression of a persistently active protein kinase C isoform enhances memories long after they have been formed.
