Contents
Vol 4, Issue 164
Contents
Research Article
- LRP6 Mediates cAMP Generation by G Protein–Coupled Receptors Through Regulating the Membrane Targeting of Gαs
The receptor LRP6 associates with Gαs to promote cAMP signaling by various GPCRs.
Research Resources
- Engineering the ABA Plant Stress Pathway for Regulation of Induced Proximity
An abscisic acid–induced proximity system can be used in combination with other such systems to simultaneously control multiple cellular processes.
- System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation
Dynamic phosphorylation during stem cell differentiation may control recruitment of DNA methyltransferases to silence genes that maintain pluripotency.
Perspective
- Inducible Gene Expression in Mammals: Plants Add to the Menu
The plant abscisic acid signaling components can be leveraged to inducibly control protein interactions in mammals.
Podcast
- Science Signaling Podcast: 15 March 2011
A protein required for light sensation also plays a role in thermosensing in the fruit fly.
Editors' Choice
- Healed into Cancer
Recruitment of hair stem cells with activating mutations in the Hedgehog pathway to sites of skin injury leads to tumor formation.
- Inflamed About Retinoic Acid
In the presence of interleukin-15, retinoic acid appears to promote an intestinal inflammatory response.
- Feeling the Heat
The light sensor rhodopsin appears to function also in temperature sensation in the fruit fly.
- Messing with the Brakes
An additional point of contact with its regulatory subunit distinguishes p110β from other class IA PI3K isoforms.
- Forcefully Translated
Activation of integrins on oligodendrocytes promotes translation of the mRNA encoding a myelin sheath component.
- Bacterial-Host Exploitation
A virulence factor secreted by Listeria monocytogenes induces expression of interferon-stimulated genes.
- Metabolic Lags
Circadian control of liver metabolism is mediated by cycles of recruitment of the histone deacetylase HDAC3.
- Tissues Simply
An epithelium in Dictyostelium discoideum suggests convergence between multicellular animals and slime molds.
