Contents
Vol 4, Issue 165
Contents
Research Article
- In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF-α–Induced Apoptosis and Proliferation by MAPKs
A systems-level analysis of signaling in the mouse intestine identifies critical mediators of inflammation and regionally specific responses.
Perspective
- CD69: An Unexpected Regulator of TH17 Cell–Driven Inflammatory Responses
CD69 deficiency promotes differentiation of inflammatory TH17 cells and exacerbates autoimmune diseases in mice.
Meeting Report
- The Yin and Yang of Signaling in Tregs and TH17 Cells
This meeting in Shanghai focused on the relationship between regulatory and inflammatory T cells.
Editors' Choice
- Getting Rid of Unwanted Neighbors
JNK signaling promotes the elimination of neoplastic cells in Drosophila epithelia.
- Retinol Gets In on the Act
The binding of vitamin A to its uptake receptor activates JAK-STAT signaling and gene expression.
- Activating CatSper
Progesterone stimulates calcium influx in human sperm through the CatSper channel.
- Chromatin-Associated PKC
Protein kinase C-θ acts directly at gene promoters to participate in inducible gene expression.
- The Brain’s Alarm Clock
Neurons in the brain that boost the morning response of the circadian rhythm are themselves directly responsive to light.
- Limiting Heart Hypertrophy
Reducing the abundance of follistatin-like 3, a secreted antagonist of members of the transforming growth factor–β family, reduces cardiac hypertrophy.
