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Research ArticleSystems Biology
In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF-α–Induced Apoptosis and Proliferation by MAPKs
- Ken S. Lau1,2,3,
- Alwin M. Juchheim1,2,
- Kimberly R. Cavaliere1,
- Sarah R. Philips1,
- Douglas A. Lauffenburger3, and
- Kevin M. Haigis1,2,*
- 1Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
- 2Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
- 3Department of Biological Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- ↵*To whom correspondence should be addressed. E-mail: khaigis{at}partners.org
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Science Signaling 22 Mar 2011:
Vol. 4, Issue 165, pp. ra16
DOI: 10.1126/scisignal.2001338
Vol. 4, Issue 165, pp. ra16
DOI: 10.1126/scisignal.2001338
Ken S. Lau
1Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
2Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
3Department of Biological Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Alwin M. Juchheim
1Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
2Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Kimberly R. Cavaliere
1Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Sarah R. Philips
1Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Douglas A. Lauffenburger
3Department of Biological Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kevin M. Haigis
1Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
2Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
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