Contents

Contents

• Editorial Guide

  • Focus Issue: Rendering Resistance Futile

    By Elizabeth M. Adler, Nancy R. Gough

    Science Signaling29 Mar 2011 : eg3 Full AccessRestricted Access

    Understanding the pathways that mediate drug resistance is key to developing new cancer therapies.

    • Abstract
    • Full Text
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• Research Articles

  • Amplification of the Driving Oncogene, KRAS or BRAF, Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells

    By Annette S. Little, Kathryn Balmanno, Matthew J. Sale, Scott Newman, Jonathan R. Dry, Mark Hampson, Paul A. W. Edwards, Paul D. Smith, Simon J. Cook

    Science Signaling29 Mar 2011 : ra17 Full AccessRestricted Access

    Resistance to cancer therapeutics targeting the second kinase in a three-kinase cascade involves amplification of the upstream kinase, not the inhibited kinase.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Global Phosphoproteomics Reveals Crosstalk Between Bcr-Abl and Negative Feedback Mechanisms Controlling Src Signaling

    By Liudmilla Rubbi, Björn Titz, Lauren Brown, Erica Galvan, Evangelia Komisopoulou, Sharon S. Chen, Tracey Low, Martik Tahmasian, Brian Skaggs, Markus Müschen, Matteo Pellegrini, Thomas G. Graeber

    Science Signaling29 Mar 2011 : ra18 Full AccessRestricted Access

    Negative feedback fails to limit Src family kinase activity in the presence of Bcr-Abl, an oncoprotein that drives leukemia.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • c-MYC Suppresses BIN1 to Release Poly(ADP-Ribose) Polymerase 1: A Mechanism by Which Cancer Cells Acquire Cisplatin Resistance

    By Slovénie Pyndiah, Satoshi Tanida, Kazi M. Ahmed, Erica K. Cassimere, Chungyoul Choe, Daitoku Sakamuro

    Science Signaling29 Mar 2011 : ra19 Full AccessRestricted Access

    c-MYC promotes cisplatin resistance by enabling the increased activity of a DNA repair enzyme.

    • Editor's Summary
    • Abstract
    • Full Text
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• Perspectives

  • MYC, PARP1, and Chemoresistance: BIN There, Done That?

    By Shridar Ganesan

    Science Signaling29 Mar 2011 : pe15 Full AccessRestricted Access

    Enhanced capacity for DNA repair may contribute to chemoresistance in cancers with dysregulated c-MYC.

    • Abstract
    • Full Text
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  • Resistance to MEK Inhibitors: Should We Co-Target Upstream?

    By Poulikos I. Poulikakos, David B. Solit

    Science Signaling29 Mar 2011 : pe16 Full AccessRestricted Access

    Amplification of an upstream kinase in a three-kinase module confers resistance to cancer drugs that target a downstream kinase.

    • Abstract
    • Full Text
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• Podcast

  • Science Signaling Podcast: 29 March 2011

    By Thomas G. Graeber, Annalisa M. VanHook

    Science Signaling29 Mar 2011 : pc6 Full AccessRestricted Access

    Negative feedback mechanisms fail to limit Src family kinase activity in leukemias driven by the oncoprotein Bcr-Abl.

    • Abstract
    • Full Text

• Editors' Choice

  • Degraded for Shock Value

    By Wei Wong

    Science Signaling29 Mar 2011 : ec89 Full AccessRestricted Access

    A glycoprotein secreted by a parasitic nematode inhibits TLR4 signaling and could be used to treat sepsis.

    • Abstract

  • Activated by Cleavage

    By John F. Foley

    Science Signaling29 Mar 2011 : ec90 Full AccessRestricted Access

    An avian Toll-like receptor is cleaved and activated by virulence-associated fungal and bacterial proteases.

    • Abstract

  • Pancreatic Cancer Immunotherapy

    By Kristen L. Mueller

    Science Signaling29 Mar 2011 : ec91 Full AccessRestricted Access

    CD40 immunotherapy shows efficacy in treating pancreatic cancer in mice and humans by eliciting antitumor immunity.

    • Abstract

  • From Fat Body to Glia to Neuroblasts

    By Elizabeth M. Adler

    Science Signaling29 Mar 2011 : ec92 Full AccessRestricted Access

    A fat-body–derived signal to glia leads to their release of insulin-like peptides to stimulate neuroblast reactivation.

    • Abstract

  • FGF19 and Liver Metabolism

    By L. Bryan Ray

    Science Signaling29 Mar 2011 : ec93 Full AccessRestricted Access

    Fibroblast growth factor 19 regulates liver metabolism through a mechanism distinct from that of insulin.

    • Abstract