Contents
Vol 4, Issue 166
Contents
Editorial Guide
- Focus Issue: Rendering Resistance Futile
Understanding the pathways that mediate drug resistance is key to developing new cancer therapies.
Research Articles
- Amplification of the Driving Oncogene, KRAS or BRAF, Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells
Resistance to cancer therapeutics targeting the second kinase in a three-kinase cascade involves amplification of the upstream kinase, not the inhibited kinase.
- Global Phosphoproteomics Reveals Crosstalk Between Bcr-Abl and Negative Feedback Mechanisms Controlling Src Signaling
Negative feedback fails to limit Src family kinase activity in the presence of Bcr-Abl, an oncoprotein that drives leukemia.
- c-MYC Suppresses BIN1 to Release Poly(ADP-Ribose) Polymerase 1: A Mechanism by Which Cancer Cells Acquire Cisplatin Resistance
c-MYC promotes cisplatin resistance by enabling the increased activity of a DNA repair enzyme.
Perspectives
- MYC, PARP1, and Chemoresistance: BIN There, Done That?
Enhanced capacity for DNA repair may contribute to chemoresistance in cancers with dysregulated c-MYC.
- Resistance to MEK Inhibitors: Should We Co-Target Upstream?
Amplification of an upstream kinase in a three-kinase module confers resistance to cancer drugs that target a downstream kinase.
Podcast
- Science Signaling Podcast: 29 March 2011
Negative feedback mechanisms fail to limit Src family kinase activity in leukemias driven by the oncoprotein Bcr-Abl.
Editors' Choice
- Degraded for Shock Value
A glycoprotein secreted by a parasitic nematode inhibits TLR4 signaling and could be used to treat sepsis.
- Activated by Cleavage
An avian Toll-like receptor is cleaved and activated by virulence-associated fungal and bacterial proteases.
- Pancreatic Cancer Immunotherapy
CD40 immunotherapy shows efficacy in treating pancreatic cancer in mice and humans by eliciting antitumor immunity.
- From Fat Body to Glia to Neuroblasts
A fat-body–derived signal to glia leads to their release of insulin-like peptides to stimulate neuroblast reactivation.
- FGF19 and Liver Metabolism
Fibroblast growth factor 19 regulates liver metabolism through a mechanism distinct from that of insulin.